DegronMD - Q7Z353(HDX)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A529G	TCGA-05-4390	LUAD	TCGA	LTPGEE	DEG_SCF_FBW7_2	523:528	Mutation rewiring degron network	0.3056
p.R119K	TCGA-60-2708	LUSC	TCGA	PASSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.2778
p.L373S	TCGA-AA-3968	COAD	TCGA	LTPRTS	DEG_SCF_FBW7_1	373:378	Mutation altering degron motif	0.7667
p.V105A	TCGA-AA-A00N	COAD	TCGA	PASSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.1111
p.E535D	TCGA-AG-A002	READ	TCGA	LTPGEE	DEG_SCF_FBW7_2	523:528	Mutation rewiring degron network	0.1389
p.R369I	TCGA-AP-A0LM	UCEC	TCGA	LTPRTS	DEG_SCF_FBW7_1	373:378	Mutation rewiring degron network	0.2222
p.R369I	DO43306	UCEC	ICGC	LTPRTS	DEG_SCF_FBW7_1	373:378	Mutation rewiring degron network	0.2222
p.A382S	TCGA-AX-A0J1	UCEC	TCGA	LTPRTS	DEG_SCF_FBW7_1	373:378	Mutation rewiring degron network	0.2222
p.E528K	TCGA-AX-A1CE	UCEC	TCGA	LTPGEE	DEG_SCF_FBW7_2	523:528	Mutation altering degron motif	0.7022
p.E528K	DO42280	UCEC	ICGC	LTPGEE	DEG_SCF_FBW7_2	523:528	Mutation altering degron motif	0.7022
p.G526V	TCGA-B6-A0RG	BRCA	TCGA	LTPGEE	DEG_SCF_FBW7_2	523:528	Mutation altering degron motif	0.6421
p.G526V	DO2353	BRCA	ICGC	LTPGEE	DEG_SCF_FBW7_2	523:528	Mutation altering degron motif	0.6421
p.D104N	TCGA-BK-A6W3	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.0833
p.D104N	DO50076	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.0833
p.Y111C	TCGA-BR-4184	STAD	TCGA	PASSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.2778
p.L523P	TCGA-CK-5913	COAD	TCGA	LTPGEE	DEG_SCF_FBW7_2	523:528	Mutation altering degron motif	0.6471
p.Q514E	TCGA-CN-5364	HNSC	TCGA	LTPGEE	DEG_SCF_FBW7_2	523:528	Mutation rewiring degron network	0.0833
p.I110M	TCGA-CV-6952	HNSC	TCGA	PASSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.25
p.I110M	DO14240	HNSC	ICGC	PASSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.25
p.I110M	DO49129	PACA	ICGC	PASSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.25
p.R376L	TCGA-CV-A45W	HNSC	TCGA	LTPRTS	DEG_SCF_FBW7_1	373:378	Mutation altering degron motif	0.7316
p.A114T	TCGA-D1-A0ZO	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	113:117	Mutation altering degron motif	0.6028
p.G109C	TCGA-D3-A2JP	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.2222
p.G109C	SIDM00085	Glioma	GDSC	PASSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.2222
p.G109C	ACH-000655	Brain Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.2222
p.G109C	SF268	central nervous system	COSMIC	PASSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.2222
p.E532K	TCGA-DA-A1HW	SKCM	TCGA	LTPGEE	DEG_SCF_FBW7_2	523:528	Mutation rewiring degron network	0.2222
p.E532K	DO38129	SKCM	ICGC	LTPGEE	DEG_SCF_FBW7_2	523:528	Mutation rewiring degron network	0.2222
p.D127N	TCGA-DK-A6AW	BLCA	TCGA	PASSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.0556
p.D127N	TCGA-ZB-A966	THYM	TCGA	PASSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.0556
p.S112I	TCGA-EO-A22R	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.3056
p.D127Y	TCGA-FI-A2D5	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.0556
p.V107A	TCGA-FI-A2D5	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.1667
p.E532D	TCGA-VQ-A91Z	STAD	TCGA	LTPGEE	DEG_SCF_FBW7_2	523:528	Mutation rewiring degron network	0.2222
p.R376I	DO7801	COAD	ICGC	LTPRTS	DEG_SCF_FBW7_1	373:378	Mutation altering degron motif	0.6991
p.E527D	DO222874	COCA	ICGC	LTPGEE	DEG_SCF_FBW7_2	523:528	Mutation altering degron motif	0.5647
p.N537Y	DO219922	DLBC	ICGC	LTPGEE	DEG_SCF_FBW7_2	523:528	Mutation rewiring degron network	0.0833
p.T122K	DO228952	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.1944
p.P531T	DO229029	LICA	ICGC	LTPGEE	DEG_SCF_FBW7_2	523:528	Mutation rewiring degron network	0.25
p.P113T	DO229045	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	113:117	Mutation altering degron motif	0.7031
p.G530R	DO229050	LICA	ICGC	LTPGEE	DEG_SCF_FBW7_2	523:528	Mutation rewiring degron network	0.2778
p.K523I	DO219197	LUSC	ICGC	LTPGEE	DEG_SCF_FBW7_2	523:528	Mutation altering degron motif	0.7531
p.E531D	DO229453	SKCA	ICGC	LTPGEE	DEG_SCF_FBW7_2	523:528	Mutation rewiring degron network	0.25
p.G371W	DO38039	SKCM	ICGC	LTPRTS	DEG_SCF_FBW7_1	373:378	Mutation rewiring degron network	0.2778
p.D520Y	DO42713	UCEC	ICGC	LTPGEE	DEG_SCF_FBW7_2	523:528	Mutation rewiring degron network	0.25
p.R381C	DO42673	UCEC	ICGC	LTPRTS	DEG_SCF_FBW7_1	373:378	Mutation rewiring degron network	0.25
p.I526N	DO43971	UCEC	ICGC	LTPGEE	DEG_SCF_FBW7_2	523:528	Mutation altering degron motif	0.728
p.L523R	SIDM01285	Esophageal Carcinoma	GDSC	LTPGEE	DEG_SCF_FBW7_2	523:528	Mutation altering degron motif	0.8428
p.V364I	SIDM02015	Colorectal Carcinoma	GDSC	LTPRTS	DEG_SCF_FBW7_1	373:378	Mutation rewiring degron network	0.0833
p.P375S	SIDM00007	Other Solid Cancers	GDSC	LTPRTS	DEG_SCF_FBW7_1	373:378	Mutation altering degron motif	0.6752
p.P375S	ACH-001550	Skin Cancer	CCLE	LTPRTS	DEG_SCF_FBW7_1	373:378	Mutation altering degron motif	0.6752
p.P375S	MCC13	skin	COSMIC	LTPRTS	DEG_SCF_FBW7_1	373:378	Mutation altering degron motif	0.6752
p.S117P	SIDM01145	Gastric Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	113:117	Mutation altering degron motif	0.6752
p.S117P	ACH-000581	Gastric Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	113:117	Mutation altering degron motif	0.6752
p.S117P	NCI-SNU-16	stomach	COSMIC	PASSS	DEG_SPOP_SBC_1	113:117	Mutation altering degron motif	0.6752
p.S519F	SIDM01161	Other Sarcomas	GDSC	LTPGEE	DEG_SCF_FBW7_2	523:528	Mutation rewiring degron network	0.2222
p.S519F	ACH-001274	Sarcoma	CCLE	LTPGEE	DEG_SCF_FBW7_2	523:528	Mutation rewiring degron network	0.2222
p.S519F	SW982	soft tissue	COSMIC	LTPGEE	DEG_SCF_FBW7_2	523:528	Mutation rewiring degron network	0.2222
p.S378L	SIDM00381	Cervical Carcinoma	GDSC	LTPRTS	DEG_SCF_FBW7_1	373:378	Mutation altering degron motif	0.7667
p.S378L	ACH-002020	Cervical Cancer	CCLE	LTPRTS	DEG_SCF_FBW7_1	373:378	Mutation altering degron motif	0.7667
p.S378L	SKG-IIIa	cervix	COSMIC	LTPRTS	DEG_SCF_FBW7_1	373:378	Mutation altering degron motif	0.7667
p.T126A	SIDM01608	Endometrial Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.0833
p.T126A	ACH-000990	Endometrial/Uterine Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.0833
p.D533N	CAL-148	breast	COSMIC	LTPGEE	DEG_SCF_FBW7_2	523:528	Mutation rewiring degron network	0.1944
p.R387Q	BALL-1	haematopoietic and lymphoid tissue	COSMIC	LTPRTS	DEG_SCF_FBW7_1	373:378	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HDX

UniProt ID: Q7Z353

Entrez ID: 139324

Protein name: Highly divergent homeobox

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HDX in