DegronMD

Uniprot ID: Q7Z353

Source protein: Highly divergent homeobox

Source gene: HDX

Class: DEG_SCF_FBW7_1

Location: 373:378

E3 ligase: FBXW7

DEGRON score: 0.9926

ASA_SCORE: 82.4833

COIL: 0.8267

CONS_SCORE: 0.6919

DSS_SCORE: 0.4801

HELIX: 0.0595

FCONS_SCORE: 1.3595

RIG_SCORE: 0.7219

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L373S	TCGA-AA-3968	COAD	TCGA	LTPRTS	DEG_SCF_FBW7_1	0.7667
p.R369I	TCGA-AP-A0LM	UCEC	TCGA	LTPRTS	DEG_SCF_FBW7_1	0.2222
p.R369I	DO43306	UCEC	ICGC	LTPRTS	DEG_SCF_FBW7_1	0.2222
p.A382S	TCGA-AX-A0J1	UCEC	TCGA	LTPRTS	DEG_SCF_FBW7_1	0.2222
p.R376L	TCGA-CV-A45W	HNSC	TCGA	LTPRTS	DEG_SCF_FBW7_1	0.7316
p.R376I	DO7801	COAD	ICGC	LTPRTS	DEG_SCF_FBW7_1	0.6991
p.G371W	DO38039	SKCM	ICGC	LTPRTS	DEG_SCF_FBW7_1	0.2778
p.R381C	DO42673	UCEC	ICGC	LTPRTS	DEG_SCF_FBW7_1	0.25
p.V364I	SIDM02015	Colorectal Carcinoma	GDSC	LTPRTS	DEG_SCF_FBW7_1	0.0833
p.P375S	SIDM00007	Other Solid Cancers	GDSC	LTPRTS	DEG_SCF_FBW7_1	0.6752
p.P375S	ACH-001550	Skin Cancer	CCLE	LTPRTS	DEG_SCF_FBW7_1	0.6752
p.P375S	MCC13	skin	COSMIC	LTPRTS	DEG_SCF_FBW7_1	0.6752
p.S378L	SIDM00381	Cervical Carcinoma	GDSC	LTPRTS	DEG_SCF_FBW7_1	0.7667
p.S378L	ACH-002020	Cervical Cancer	CCLE	LTPRTS	DEG_SCF_FBW7_1	0.7667
p.S378L	SKG-IIIa	cervix	COSMIC	LTPRTS	DEG_SCF_FBW7_1	0.7667
p.R387Q	BALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	LTPRTS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z353	Highly divergent homeobox	DEG_SCF_FBW7_1	373:378	LTPRTS	FBXW7	0.9926	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons