DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LTPIIS
Uniprot ID:
Q9P260
Source protein:
RAB11-binding protein RELCH
Source gene:
RELCH
Class:
DEG_SCF_FBW7_1
Location:
336:341
E3 ligase:
FBXW7
DEGRON score:
0.9941
ASA_SCORE:
70.1667
COIL:
0.614
CONS_SCORE:
0.3795
DSS_SCORE:
0.4983
HELIX:
0.3388
FCONS_SCORE:
1.0259
RIG_SCORE:
0.7831
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with RELCH mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LTPIIS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9P260
RAB11-binding protein RELCH
DEG_SCF_FBW7_1
336:341
LTPIIS
FBXW7
0.9941
More...