DegronMD

Uniprot ID: Q86SU0

Source protein: Immunoglobulin-like domain-containing receptor 1

Source gene: ILDR1

Class: DEG_SCF_FBW7_1

Location: 354:359

E3 ligase: FBXW7

DEGRON score: 0.9822

ASA_SCORE: 90.35

COIL: 0.9575

CONS_SCORE: 0.5191

DSS_SCORE: 0.3877

HELIX: 0.026

FCONS_SCORE: 0.9875

RIG_SCORE: 0.7048

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D363N	TCGA-90-A4ED	LUSC	TCGA	LTPIPS	DEG_SCF_FBW7_1	0.2222
p.D363N	ACH-001569	Skin Cancer	CCLE	LTPIPS	DEG_SCF_FBW7_1	0.2222
p.G367E	TCGA-DA-A3F8	SKCM	TCGA	LTPIPS	DEG_SCF_FBW7_1	0.1111
p.G367E	TCGA-EE-A29D	SKCM	TCGA	LTPIPS	DEG_SCF_FBW7_1	0.1111
p.G367E	TCGA-YG-AA3O	SKCM	TCGA	LTPIPS	DEG_SCF_FBW7_1	0.1111
p.G367E	SIDM00545	Melanoma	GDSC	LTPIPS	DEG_SCF_FBW7_1	0.1111
p.G367E	ACH-000987	Skin Cancer	CCLE	LTPIPS	DEG_SCF_FBW7_1	0.1111
p.G367E	Mewo	skin	COSMIC	LTPIPS	DEG_SCF_FBW7_1	0.1111
p.P358S	TCGA-EE-A2GL	SKCM	TCGA	LTPIPS	DEG_SCF_FBW7_1	0.5641
p.P358S	TCGA-EE-A3J5	SKCM	TCGA	LTPIPS	DEG_SCF_FBW7_1	0.5641
p.P358S	TCGA-FR-A726	SKCM	TCGA	LTPIPS	DEG_SCF_FBW7_1	0.5641
p.P358S	TCGA-FR-A8YC	SKCM	TCGA	LTPIPS	DEG_SCF_FBW7_1	0.5641
p.P358S	TCGA-GF-A6C9	SKCM	TCGA	LTPIPS	DEG_SCF_FBW7_1	0.5641
p.P358S	TCGA-W3-AA1Q	SKCM	TCGA	LTPIPS	DEG_SCF_FBW7_1	0.5641
p.P358S	SIDM01106	Melanoma	GDSC	LTPIPS	DEG_SCF_FBW7_1	0.5641
p.P358S	ACH-000822	Skin Cancer	CCLE	LTPIPS	DEG_SCF_FBW7_1	0.5641
p.P358S	SK-MEL-24	skin	COSMIC	LTPIPS	DEG_SCF_FBW7_1	0.5641
p.R365M	TCGA-EE-A2GT	SKCM	TCGA	LTPIPS	DEG_SCF_FBW7_1	0.1667
p.E366Q	TCGA-YD-A9TA	SKCM	TCGA	LTPIPS	DEG_SCF_FBW7_1	0.1389
p.P345L	DO222960	BTCA	ICGC	LTPIPS	DEG_SCF_FBW7_1	0.0833
p.P345L	DO50668	ORCA	ICGC	LTPIPS	DEG_SCF_FBW7_1	0.0833
p.P345L	DO51271	SKCM	ICGC	LTPIPS	DEG_SCF_FBW7_1	0.0833
p.F350L	DO219732	CESC	ICGC	LTPIPS	DEG_SCF_FBW7_1	0.2222
p.R361M	DO7938	COAD	ICGC	LTPIPS	DEG_SCF_FBW7_1	0.2778
p.S362N	DO48224	ESCA	ICGC	LTPIPS	DEG_SCF_FBW7_1	0.25
p.D364G	DO44440	HNSC	ICGC	LTPIPS	DEG_SCF_FBW7_1	0.1944
p.R359H	DO50224	LGG	ICGC	LTPIPS	DEG_SCF_FBW7_1	0.8244
p.R360K	DO220853	MELA	ICGC	LTPIPS	DEG_SCF_FBW7_1	0.3056
p.E347K	DO37798	SKCM	ICGC	LTPIPS	DEG_SCF_FBW7_1	0.1389
p.P349L	DO47317	SKCM	ICGC	LTPIPS	DEG_SCF_FBW7_1	0.1944
p.S366L	DO47569	SKCM	ICGC	LTPIPS	DEG_SCF_FBW7_1	0.1389
p.R344W	DO38795	STAD	ICGC	LTPIPS	DEG_SCF_FBW7_1	0.0556
p.Q352H	SIDM00210	Ovarian Carcinoma	GDSC	LTPIPS	DEG_SCF_FBW7_1	0.2778
p.Q352H	SIDM00673	Breast Carcinoma	GDSC	LTPIPS	DEG_SCF_FBW7_1	0.2778
p.G367R	SIDM00282	Colorectal Carcinoma	GDSC	LTPIPS	DEG_SCF_FBW7_1	0.1111
p.G367R	ACH-000998	Colon/Colorectal Cancer	CCLE	LTPIPS	DEG_SCF_FBW7_1	0.1111
p.G367R	CW-2	large_intestine	COSMIC	LTPIPS	DEG_SCF_FBW7_1	0.1111
p.P349S	M14	skin	COSMIC	LTPIPS	DEG_SCF_FBW7_1	0.1944
p.P349S	MEL-HO	skin	COSMIC	LTPIPS	DEG_SCF_FBW7_1	0.1944
p.R353C	SW626	ovary	COSMIC	LTPIPS	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPIPS

Degron related mutations and impact score

Drug responses associated with ILDR1 mutations

All proteins holding degron of LTPIPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86SU0	Immunoglobulin-like domain-containing receptor 1	DEG_SCF_FBW7_1	354:359	LTPIPS	FBXW7	0.9822	More...