DegronMD

Uniprot ID: Q6ZMS4

Source protein: Zinc finger protein 852

Source gene: ZNF852

Class: DEG_SCF_FBW7_2

Location: 57:62

E3 ligase: FBXW7

DEGRON score: 0.9786

ASA_SCORE: 79.6333

COIL: 0.6852

CONS_SCORE: 1

DSS_SCORE: 0.6106

HELIX: 0.1193

FCONS_SCORE: 1

RIG_SCORE: 0.7296

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E62D	TCGA-AA-3984	COAD	TCGA	LTPKQE	DEG_SCF_FBW7_2	0.6758
p.E62D	TCGA-B5-A1MR	UCEC	TCGA	LTPKQE	DEG_SCF_FBW7_2	0.6758
p.E62D	DO9002	COAD	ICGC	LTPKQE	DEG_SCF_FBW7_2	0.6758
p.E62D	DO41758	UCEC	ICGC	LTPKQE	DEG_SCF_FBW7_2	0.6758
p.Q61R	TCGA-D1-A15X	UCEC	TCGA	LTPKQE	DEG_SCF_FBW7_2	0.6218
p.Q61R	DO43274	UCEC	ICGC	LTPKQE	DEG_SCF_FBW7_2	0.6218
p.E62A	TCGA-EI-6917	READ	TCGA	LTPKQE	DEG_SCF_FBW7_2	0.7701
p.E62A	DO36881	READ	ICGC	LTPKQE	DEG_SCF_FBW7_2	0.7701
p.P59L	SIDM00659	Glioblastoma	GDSC	LTPKQE	DEG_SCF_FBW7_2	0.7582
p.P59L	ACH-000152	Brain Cancer	CCLE	LTPKQE	DEG_SCF_FBW7_2	0.7582
p.P59L	ACH-001118	Brain Cancer	CCLE	LTPKQE	DEG_SCF_FBW7_2	0.7582
p.P59L	M059J	central_nervous_system	COSMIC	LTPKQE	DEG_SCF_FBW7_2	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P0L1	Zinc finger protein with KRAB and SCAN domains 7	DEG_SCF_FBW7_2	281:286	LTPKQE	FBXW7	0.9918	More...
Q6ZMS4	Zinc finger protein 852	DEG_SCF_FBW7_2	57:62	LTPKQE	FBXW7	0.9786	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons