DegronMD

Uniprot ID: Q9P0L1

Source protein: Zinc finger protein with KRAB and SCAN domains 7

Source gene: ZKSCAN7

Class: DEG_SCF_FBW7_2

Location: 281:286

E3 ligase: FBXW7

DEGRON score: 0.9918

ASA_SCORE: 89.25

COIL: 0.6772

CONS_SCORE: 0.6373

DSS_SCORE: 0.6011

HELIX: 0.1405

FCONS_SCORE: 1.044

RIG_SCORE: 0.7352

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F287L	TCGA-21-1080	LUSC	TCGA	LTPKQE	DEG_SCF_FBW7_2	0.3056
p.F287L	TCGA-B5-A11E	UCEC	TCGA	LTPKQE	DEG_SCF_FBW7_2	0.3056
p.F287L	DO26502	LUSC	ICGC	LTPKQE	DEG_SCF_FBW7_2	0.3056
p.F287L	DO41644	UCEC	ICGC	LTPKQE	DEG_SCF_FBW7_2	0.3056
p.K277E	TCGA-BR-8366	STAD	TCGA	LTPKQE	DEG_SCF_FBW7_2	0.3333
p.K277E	DO47791	STAD	ICGC	LTPKQE	DEG_SCF_FBW7_2	0.3333
p.M276I	TCGA-VS-A8Q9	CESC	TCGA	LTPKQE	DEG_SCF_FBW7_2	0.1944
p.M276I	DO51626	CESC	ICGC	LTPKQE	DEG_SCF_FBW7_2	0.1944
p.S291P	DO234459	ESAD	ICGC	LTPKQE	DEG_SCF_FBW7_2	0.6389
p.G272C	DO229026	LICA	ICGC	LTPKQE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P0L1	Zinc finger protein with KRAB and SCAN domains 7	DEG_SCF_FBW7_2	281:286	LTPKQE	FBXW7	0.9918	More...
Q6ZMS4	Zinc finger protein 852	DEG_SCF_FBW7_2	57:62	LTPKQE	FBXW7	0.9786	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons