DegronMD

Uniprot ID: P10244

Source protein: Myb-related protein B

Source gene: MYBL2

Class: DEG_SCF_FBW7_1

Location: 439:444

E3 ligase: FBXW7

DEGRON score: 0.9933

ASA_SCORE: 98.3333

COIL: 0.9582

CONS_SCORE: 0.3361

DSS_SCORE: 0.3456

HELIX: 0.0137

FCONS_SCORE: 0.9323

RIG_SCORE: 0.6918

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D434Y	TCGA-64-5774	LUAD	TCGA	LTPKST	DEG_SCF_FBW7_1	0.1944
p.S435F	TCGA-90-A4ED	LUSC	TCGA	LTPKST	DEG_SCF_FBW7_1	0.2222
p.S452L	TCGA-A5-A2K3	UCEC	TCGA	LTPKST	DEG_SCF_FBW7_1	0.5556
p.P453S	TCGA-AP-A1DR	UCEC	TCGA	LTPKST	DEG_SCF_FBW7_1	0.0833
p.P445A	TCGA-BC-A10U	LIHC	TCGA	LTPKST	DEG_SCF_FBW7_1	0.3056
p.S438I	TCGA-ER-A19N	SKCM	TCGA	LTPKST	DEG_SCF_FBW7_1	0.3056
p.V446L	TCGA-FT-A61P	BLCA	TCGA	LTPKST	DEG_SCF_FBW7_1	0.2778
p.S454F	TCGA-GU-AATO	BLCA	TCGA	LTPKST	DEG_SCF_FBW7_1	0.5
p.S430F	DO51893	BLCA	ICGC	LTPKST	DEG_SCF_FBW7_1	0.0833
p.L449Q	DO223933	BRCA	ICGC	LTPKST	DEG_SCF_FBW7_1	0.1944
p.T450K	DO10582	COAD	ICGC	LTPKST	DEG_SCF_FBW7_1	0.1667
p.S448L	DO224544	LUSC	ICGC	LTPKST	DEG_SCF_FBW7_1	0.2222
p.S448L	DO231014	LUSC	ICGC	LTPKST	DEG_SCF_FBW7_1	0.2222
p.E445D	DO43186	UCEC	ICGC	LTPKST	DEG_SCF_FBW7_1	0.3056
p.P429S	DO43747	UCEC	ICGC	LTPKST	DEG_SCF_FBW7_1	0.0556
p.T440A	SIDM01424	B-Lymphoblastic Leukemia	GDSC	LTPKST	DEG_SCF_FBW7_1	0.825
p.T440A	ACH-000782	Leukemia	CCLE	LTPKST	DEG_SCF_FBW7_1	0.825
p.T440A	ACH-001735	Leukemia	CCLE	LTPKST	DEG_SCF_FBW7_1	0.825
p.T441I	NCI-H630	large_intestine	COSMIC	LTPKST	DEG_SCF_FBW7_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10244	Myb-related protein B	DEG_SCF_FBW7_1	439:444	LTPKST	FBXW7	0.9933	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons