DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_1

Location: 10652:10657

E3 ligase: FBXW7

DEGRON score: 0.5785

ASA_SCORE: 86.8333

COIL: 0.7537

CONS_SCORE: 0

DSS_SCORE: 0.4988

HELIX: 0.0168

FCONS_SCORE: 0

RIG_SCORE: 0.779

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P10646S	TCGA-61-2110	OV	TCGA	LTPLVT	DEG_SCF_FBW7_1	0.1667
p.P10646S	DO27979	OV	ICGC	LTPLVT	DEG_SCF_FBW7_1	0.1667
p.A10651P	TCGA-95-A4VN	LUAD	TCGA	LTPLVT	DEG_SCF_FBW7_1	0.3056
p.A10651P	TCGA-CV-7091	HNSC	TCGA	LTPLVT	DEG_SCF_FBW7_1	0.3056
p.A10651P	DO14212	HNSC	ICGC	LTPLVT	DEG_SCF_FBW7_1	0.3056
p.A10651P	DO51199	LUAD	ICGC	LTPLVT	DEG_SCF_FBW7_1	0.3056
p.A10651S	TCGA-AG-A01Y	READ	TCGA	LTPLVT	DEG_SCF_FBW7_1	0.3056
p.A10651S	DO37396	READ	ICGC	LTPLVT	DEG_SCF_FBW7_1	0.3056
p.F10667L	TCGA-AX-A1CI	UCEC	TCGA	LTPLVT	DEG_SCF_FBW7_1	0.0556
p.F10667L	DO42544	UCEC	ICGC	LTPLVT	DEG_SCF_FBW7_1	0.0556
p.S10659L	TCGA-BS-A0UV	UCEC	TCGA	LTPLVT	DEG_SCF_FBW7_1	0.2778
p.S10659L	TCGA-D3-A2JP	SKCM	TCGA	LTPLVT	DEG_SCF_FBW7_1	0.2778
p.S10659L	TCGA-EE-A2MS	SKCM	TCGA	LTPLVT	DEG_SCF_FBW7_1	0.2778
p.S10659L	TCGA-G4-6302	COAD	TCGA	LTPLVT	DEG_SCF_FBW7_1	0.2778
p.S10659L	TCGA-GN-A4U4	SKCM	TCGA	LTPLVT	DEG_SCF_FBW7_1	0.2778
p.S10659L	DO8778	COAD	ICGC	LTPLVT	DEG_SCF_FBW7_1	0.2778
p.S10659L	DO220861	MELA	ICGC	LTPLVT	DEG_SCF_FBW7_1	0.2778
p.S10659L	DO222402	MELA	ICGC	LTPLVT	DEG_SCF_FBW7_1	0.2778
p.S10659L	DO37567	SKCM	ICGC	LTPLVT	DEG_SCF_FBW7_1	0.2778
p.S10659L	DO47407	SKCM	ICGC	LTPLVT	DEG_SCF_FBW7_1	0.2778
p.S10659L	DO51256	SKCM	ICGC	LTPLVT	DEG_SCF_FBW7_1	0.2778
p.S10659L	DO42793	UCEC	ICGC	LTPLVT	DEG_SCF_FBW7_1	0.2778
p.P10646T	TCGA-CJ-5671	KIRC	TCGA	LTPLVT	DEG_SCF_FBW7_1	0.1667
p.P10646T	DO16560	KIRC	ICGC	LTPLVT	DEG_SCF_FBW7_1	0.1667
p.D10662V	TCGA-DD-AAE7	LIHC	TCGA	LTPLVT	DEG_SCF_FBW7_1	0.1944
p.D10662V	DO52262	LIHC	ICGC	LTPLVT	DEG_SCF_FBW7_1	0.1944
p.S10645L	TCGA-DK-AA71	BLCA	TCGA	LTPLVT	DEG_SCF_FBW7_1	0.1389
p.S10645L	DO219010	BLCA	ICGC	LTPLVT	DEG_SCF_FBW7_1	0.1389
p.T10665S	DO229003	COCA	ICGC	LTPLVT	DEG_SCF_FBW7_1	0.1111
p.L10655Q	DO231992	LICA	ICGC	LTPLVT	DEG_SCF_FBW7_1	0.6654
p.T10665K	DO228985	LICA	ICGC	LTPLVT	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPLVT

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of LTPLVT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	10652:10657	LTPLVT	FBXW7	0.5785	More...