DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LTPNTT
Uniprot ID:
O75151
Source protein:
Lysine-specific demethylase PHF2
Source gene:
PHF2
Class:
DEG_SCF_FBW7_1
Location:
959:964
E3 ligase:
FBXW7
DEGRON score:
0.9945
ASA_SCORE:
106.7667
COIL:
0.9603
CONS_SCORE:
0.2778
DSS_SCORE:
0.6592
HELIX:
0.0192
FCONS_SCORE:
0.9555
RIG_SCORE:
0.5942
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PHF2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LTPNTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O75151
Lysine-specific demethylase PHF2
DEG_SCF_FBW7_1
959:964
LTPNTT
FBXW7
0.9945
More...