DegronMD

Uniprot ID: Q15652

Source protein: Probable JmjC domain-containing histone demethylation protein 2C

Source gene: JMJD1C

Class: DEG_SCF_FBW7_1

Location: 2000:2005

E3 ligase: FBXW7

DEGRON score: 0.9985

ASA_SCORE: 73.8

COIL: 0.83

CONS_SCORE: 0.4871

DSS_SCORE: 0.7283

HELIX: 0.1373

FCONS_SCORE: 1.0326

RIG_SCORE: 0.5931

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1991K	TCGA-17-Z061	LUAD	TCGA	LTPPES	DEG_SCF_FBW7_1	0.0833
p.P2002L	TCGA-35-4123	LUAD	TCGA	LTPPES	DEG_SCF_FBW7_1	0.7582
p.E1991D	TCGA-EO-A22R	UCEC	TCGA	LTPPES	DEG_SCF_FBW7_1	0.0833
p.S1995C	DO228278	LICA	ICGC	LTPPES	DEG_SCF_FBW7_1	0.1944
p.K2001T	DO45241	LIRI	ICGC	LTPPES	DEG_SCF_FBW7_1	0.7306
p.D1990N	DO232224	PBCA	ICGC	LTPPES	DEG_SCF_FBW7_1	0.0556
p.S1994R	DO36766	READ	ICGC	LTPPES	DEG_SCF_FBW7_1	0.1667
p.S2007P	SIDM00082	Melanoma	GDSC	LTPPES	DEG_SCF_FBW7_1	0.7222
p.S2007P	ACH-001190	Skin Cancer	CCLE	LTPPES	DEG_SCF_FBW7_1	0.7222
p.S2007P	SK-MEL-2	skin	COSMIC	LTPPES	DEG_SCF_FBW7_1	0.7222
p.Q2006L	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	LTPPES	DEG_SCF_FBW7_1	0.3056
p.Q2006L	ACH-000824	Esophageal Cancer	CCLE	LTPPES	DEG_SCF_FBW7_1	0.3056
p.Q2006L	KYSE-510	oesophagus	COSMIC	LTPPES	DEG_SCF_FBW7_1	0.3056
p.D1993V	SIDM00604	Oral Cavity Carcinoma	GDSC	LTPPES	DEG_SCF_FBW7_1	0.1389
p.D1993V	ACH-001542	Head and Neck Cancer	CCLE	LTPPES	DEG_SCF_FBW7_1	0.1389
p.D1993V	KON	upper_aerodigestive_tract	COSMIC	LTPPES	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SCF_FBW7_1	2000:2005	LTPPES	FBXW7	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons