DegronMD

Uniprot ID: Q9NQ69

Source protein: LIM/homeobox protein Lhx9

Source gene: LHX9

Class: DEG_SCF_FBW7_1

Location: 353:358

E3 ligase: FBXW7

DEGRON score: 0.9931

ASA_SCORE: 74.55

COIL: 0.9458

CONS_SCORE: 0.4471

DSS_SCORE: 0.6559

HELIX: 0.0228

FCONS_SCORE: 1.011

RIG_SCORE: 0.6332

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P368H	TCGA-A6-3809	COAD	TCGA	LTPPGT	DEG_SCF_FBW7_1	0.0556
p.A359V	TCGA-AX-A0J1	UCEC	TCGA	LTPPGT	DEG_SCF_FBW7_1	0.3056
p.A359V	DO41199	UCEC	ICGC	LTPPGT	DEG_SCF_FBW7_1	0.3056
p.T360I	TCGA-CJ-5689	KIRC	TCGA	LTPPGT	DEG_SCF_FBW7_1	0.2778
p.T360I	DO19853	KIRC	ICGC	LTPPGT	DEG_SCF_FBW7_1	0.2778
p.L353I	TCGA-D1-A17Q	UCEC	TCGA	LTPPGT	DEG_SCF_FBW7_1	0.6063
p.P355S	TCGA-EE-A2GT	SKCM	TCGA	LTPPGT	DEG_SCF_FBW7_1	0.6752
p.P355S	DO37946	SKCM	ICGC	LTPPGT	DEG_SCF_FBW7_1	0.6752
p.P355Q	TCGA-EY-A1GU	UCEC	TCGA	LTPPGT	DEG_SCF_FBW7_1	0.7035
p.A359T	TCGA-HU-A4GN	STAD	TCGA	LTPPGT	DEG_SCF_FBW7_1	0.3056
p.A359T	DO47833	STAD	ICGC	LTPPGT	DEG_SCF_FBW7_1	0.3056
p.S347L	TCGA-XF-AAMR	BLCA	TCGA	LTPPGT	DEG_SCF_FBW7_1	0.1667
p.P359H	DO8722	COAD	ICGC	LTPPGT	DEG_SCF_FBW7_1	0.3056
p.A359E	DO229010	COCA	ICGC	LTPPGT	DEG_SCF_FBW7_1	0.3056
p.G357V	DO229041	LICA	ICGC	LTPPGT	DEG_SCF_FBW7_1	0.6421
p.L344I	DO41903	UCEC	ICGC	LTPPGT	DEG_SCF_FBW7_1	0.0833
p.P346Q	DO41518	UCEC	ICGC	LTPPGT	DEG_SCF_FBW7_1	0.1389
p.P343L	SIDM01951	Colorectal Carcinoma	GDSC	LTPPGT	DEG_SCF_FBW7_1	0.0556
p.L365M	SIDM01608	Endometrial Carcinoma	GDSC	LTPPGT	DEG_SCF_FBW7_1	0.1389
p.L365M	ACH-000990	Endometrial/Uterine Cancer	CCLE	LTPPGT	DEG_SCF_FBW7_1	0.1389
p.I361V	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	LTPPGT	DEG_SCF_FBW7_1	0.25
p.I361V	S-117	soft_tissue	COSMIC	LTPPGT	DEG_SCF_FBW7_1	0.25
p.I361V	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	LTPPGT	DEG_SCF_FBW7_1	0.25
p.S366T	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	LTPPGT	DEG_SCF_FBW7_1	0.1111
p.S366T	S-117	soft_tissue	COSMIC	LTPPGT	DEG_SCF_FBW7_1	0.1111
p.S366T	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	LTPPGT	DEG_SCF_FBW7_1	0.1111
p.V367A	COLO-684	endometrium	COSMIC	LTPPGT	DEG_SCF_FBW7_1	0.0833
p.I361T	HT-29	large_intestine	COSMIC	LTPPGT	DEG_SCF_FBW7_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPPGT

Degron related mutations and impact score

Drug responses associated with LHX9 mutations

All proteins holding degron of LTPPGT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQ69	LIM/homeobox protein Lhx9	DEG_SCF_FBW7_1	353:358	LTPPGT	FBXW7	0.9931	More...