DegronMD - Q9NQ69(LHX9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L342I	TCGA-2Y-A9GZ	LIHC	TCGA	DSGALT	DEG_SCF_TRCP1_1	349:354	Mutation rewiring degron network	0.1389
p.L342I	DO219517	LIHC	ICGC	DSGALT	DEG_SCF_TRCP1_1	349:354	Mutation rewiring degron network	0.1389
p.P368H	TCGA-A6-3809	COAD	TCGA	LTPPGT	DEG_SCF_FBW7_1	353:358	Mutation rewiring degron network	0.0556
p.G351R	TCGA-A8-A07G	BRCA	TCGA	DSGALT	DEG_SCF_TRCP1_1	349:354	Mutation altering degron motif	0.7568
p.A359V	TCGA-AX-A0J1	UCEC	TCGA	LTPPGT	DEG_SCF_FBW7_1	353:358	Mutation rewiring degron network	0.3056
p.A359V	TCGA-AX-A0J1	UCEC	TCGA	DSGALT	DEG_SCF_TRCP1_1	349:354	Mutation rewiring degron network	0.1944
p.A359V	DO41199	UCEC	ICGC	LTPPGT	DEG_SCF_FBW7_1	353:358	Mutation rewiring degron network	0.3056
p.A359V	DO41199	UCEC	ICGC	DSGALT	DEG_SCF_TRCP1_1	349:354	Mutation rewiring degron network	0.1944
p.T360I	TCGA-CJ-5689	KIRC	TCGA	LTPPGT	DEG_SCF_FBW7_1	353:358	Mutation rewiring degron network	0.2778
p.T360I	TCGA-CJ-5689	KIRC	TCGA	DSGALT	DEG_SCF_TRCP1_1	349:354	Mutation rewiring degron network	0.1667
p.T360I	DO19853	KIRC	ICGC	LTPPGT	DEG_SCF_FBW7_1	353:358	Mutation rewiring degron network	0.2778
p.T360I	DO19853	KIRC	ICGC	DSGALT	DEG_SCF_TRCP1_1	349:354	Mutation rewiring degron network	0.1667
p.L353I	TCGA-D1-A17Q	UCEC	TCGA	LTPPGT	DEG_SCF_FBW7_1	353:358	Mutation altering degron motif	0.6063
p.L353I	TCGA-D1-A17Q	UCEC	TCGA	DSGALT	DEG_SCF_TRCP1_1	349:354	Mutation altering degron motif	0.6063
p.P355S	TCGA-EE-A2GT	SKCM	TCGA	LTPPGT	DEG_SCF_FBW7_1	353:358	Mutation altering degron motif	0.6752
p.P355S	DO37946	SKCM	ICGC	LTPPGT	DEG_SCF_FBW7_1	353:358	Mutation altering degron motif	0.6752
p.P355Q	TCGA-EY-A1GU	UCEC	TCGA	LTPPGT	DEG_SCF_FBW7_1	353:358	Mutation altering degron motif	0.7035
p.A359T	TCGA-HU-A4GN	STAD	TCGA	LTPPGT	DEG_SCF_FBW7_1	353:358	Mutation rewiring degron network	0.3056
p.A359T	TCGA-HU-A4GN	STAD	TCGA	DSGALT	DEG_SCF_TRCP1_1	349:354	Mutation rewiring degron network	0.1944
p.A359T	DO47833	STAD	ICGC	LTPPGT	DEG_SCF_FBW7_1	353:358	Mutation rewiring degron network	0.3056
p.A359T	DO47833	STAD	ICGC	DSGALT	DEG_SCF_TRCP1_1	349:354	Mutation rewiring degron network	0.1944
p.G339D	TCGA-VQ-A8P2	STAD	TCGA	DSGALT	DEG_SCF_TRCP1_1	349:354	Mutation rewiring degron network	0.0556
p.S347L	TCGA-XF-AAMR	BLCA	TCGA	LTPPGT	DEG_SCF_FBW7_1	353:358	Mutation rewiring degron network	0.1667
p.S347L	TCGA-XF-AAMR	BLCA	TCGA	DSGALT	DEG_SCF_TRCP1_1	349:354	Mutation rewiring degron network	0.2778
p.G342R	DO2870	BRCA	ICGC	DSGALT	DEG_SCF_TRCP1_1	349:354	Mutation rewiring degron network	0.1389
p.P359H	DO8722	COAD	ICGC	LTPPGT	DEG_SCF_FBW7_1	353:358	Mutation rewiring degron network	0.3056
p.P359H	DO8722	COAD	ICGC	DSGALT	DEG_SCF_TRCP1_1	349:354	Mutation rewiring degron network	0.1944
p.A359E	DO229010	COCA	ICGC	LTPPGT	DEG_SCF_FBW7_1	353:358	Mutation rewiring degron network	0.3056
p.A359E	DO229010	COCA	ICGC	DSGALT	DEG_SCF_TRCP1_1	349:354	Mutation rewiring degron network	0.1944
p.G357V	DO229041	LICA	ICGC	LTPPGT	DEG_SCF_FBW7_1	353:358	Mutation altering degron motif	0.6421
p.L344I	DO41903	UCEC	ICGC	LTPPGT	DEG_SCF_FBW7_1	353:358	Mutation rewiring degron network	0.0833
p.L344I	DO41903	UCEC	ICGC	DSGALT	DEG_SCF_TRCP1_1	349:354	Mutation rewiring degron network	0.1944
p.P346Q	DO41518	UCEC	ICGC	LTPPGT	DEG_SCF_FBW7_1	353:358	Mutation rewiring degron network	0.1389
p.P346Q	DO41518	UCEC	ICGC	DSGALT	DEG_SCF_TRCP1_1	349:354	Mutation rewiring degron network	0.25
p.P343L	SIDM01951	Colorectal Carcinoma	GDSC	LTPPGT	DEG_SCF_FBW7_1	353:358	Mutation rewiring degron network	0.0556
p.P343L	SIDM01951	Colorectal Carcinoma	GDSC	DSGALT	DEG_SCF_TRCP1_1	349:354	Mutation rewiring degron network	0.1667
p.L365M	SIDM01608	Endometrial Carcinoma	GDSC	LTPPGT	DEG_SCF_FBW7_1	353:358	Mutation rewiring degron network	0.1389
p.L365M	ACH-000990	Endometrial/Uterine Cancer	CCLE	LTPPGT	DEG_SCF_FBW7_1	353:358	Mutation rewiring degron network	0.1389
p.I361V	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	LTPPGT	DEG_SCF_FBW7_1	353:358	Mutation rewiring degron network	0.25
p.I361V	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	DSGALT	DEG_SCF_TRCP1_1	349:354	Mutation rewiring degron network	0.1389
p.I361V	S-117	soft tissue	COSMIC	LTPPGT	DEG_SCF_FBW7_1	353:358	Mutation rewiring degron network	0.25
p.I361V	S-117	soft tissue	COSMIC	DSGALT	DEG_SCF_TRCP1_1	349:354	Mutation rewiring degron network	0.1389
p.I361V	Daudi	haematopoietic and lymphoid tissue	COSMIC	LTPPGT	DEG_SCF_FBW7_1	353:358	Mutation rewiring degron network	0.25
p.I361V	Daudi	haematopoietic and lymphoid tissue	COSMIC	DSGALT	DEG_SCF_TRCP1_1	349:354	Mutation rewiring degron network	0.1389
p.S366T	Daudi	haematopoietic and lymphoid tissue	COSMIC	LTPPGT	DEG_SCF_FBW7_1	353:358	Mutation rewiring degron network	0.1111
p.S366T	S-117	soft tissue	COSMIC	LTPPGT	DEG_SCF_FBW7_1	353:358	Mutation rewiring degron network	0.1111
p.S366T	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	LTPPGT	DEG_SCF_FBW7_1	353:358	Mutation rewiring degron network	0.1111
p.V367A	COLO-684	endometrium	COSMIC	LTPPGT	DEG_SCF_FBW7_1	353:358	Mutation rewiring degron network	0.0833
p.I361T	HT-29	large intestine	COSMIC	LTPPGT	DEG_SCF_FBW7_1	353:358	Mutation rewiring degron network	0.25
p.I361T	HT-29	large intestine	COSMIC	DSGALT	DEG_SCF_TRCP1_1	349:354	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LHX9

UniProt ID: Q9NQ69

Entrez ID: 56956

Protein name: LIM/homeobox protein Lhx9 (LIM homeobox protein 9)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LHX9 in