DegronMD

Uniprot ID: Q9NQ69

Source protein: LIM/homeobox protein Lhx9

Source gene: LHX9

Class: DEG_SCF_TRCP1_1

Location: 349:354

E3 ligase: BTRC

DEGRON score: 0.9823

ASA_SCORE: 73.1

COIL: 0.9233

CONS_SCORE: 0.4501

DSS_SCORE: 0.6904

HELIX: 0.0373

FCONS_SCORE: 1.008

RIG_SCORE: 0.5979

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L342I	TCGA-2Y-A9GZ	LIHC	TCGA	DSGALT	DEG_SCF_TRCP1_1	0.1389
p.L342I	DO219517	LIHC	ICGC	DSGALT	DEG_SCF_TRCP1_1	0.1389
p.G351R	TCGA-A8-A07G	BRCA	TCGA	DSGALT	DEG_SCF_TRCP1_1	0.7568
p.A359V	TCGA-AX-A0J1	UCEC	TCGA	DSGALT	DEG_SCF_TRCP1_1	0.1944
p.A359V	DO41199	UCEC	ICGC	DSGALT	DEG_SCF_TRCP1_1	0.1944
p.T360I	TCGA-CJ-5689	KIRC	TCGA	DSGALT	DEG_SCF_TRCP1_1	0.1667
p.T360I	DO19853	KIRC	ICGC	DSGALT	DEG_SCF_TRCP1_1	0.1667
p.L353I	TCGA-D1-A17Q	UCEC	TCGA	DSGALT	DEG_SCF_TRCP1_1	0.6063
p.A359T	TCGA-HU-A4GN	STAD	TCGA	DSGALT	DEG_SCF_TRCP1_1	0.1944
p.A359T	DO47833	STAD	ICGC	DSGALT	DEG_SCF_TRCP1_1	0.1944
p.G339D	TCGA-VQ-A8P2	STAD	TCGA	DSGALT	DEG_SCF_TRCP1_1	0.0556
p.S347L	TCGA-XF-AAMR	BLCA	TCGA	DSGALT	DEG_SCF_TRCP1_1	0.2778
p.G342R	DO2870	BRCA	ICGC	DSGALT	DEG_SCF_TRCP1_1	0.1389
p.P359H	DO8722	COAD	ICGC	DSGALT	DEG_SCF_TRCP1_1	0.1944
p.A359E	DO229010	COCA	ICGC	DSGALT	DEG_SCF_TRCP1_1	0.1944
p.L344I	DO41903	UCEC	ICGC	DSGALT	DEG_SCF_TRCP1_1	0.1944
p.P346Q	DO41518	UCEC	ICGC	DSGALT	DEG_SCF_TRCP1_1	0.25
p.P343L	SIDM01951	Colorectal Carcinoma	GDSC	DSGALT	DEG_SCF_TRCP1_1	0.1667
p.I361V	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	DSGALT	DEG_SCF_TRCP1_1	0.1389
p.I361V	S-117	soft_tissue	COSMIC	DSGALT	DEG_SCF_TRCP1_1	0.1389
p.I361V	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DSGALT	DEG_SCF_TRCP1_1	0.1389
p.I361T	HT-29	large_intestine	COSMIC	DSGALT	DEG_SCF_TRCP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQ69	LIM/homeobox protein Lhx9	DEG_SCF_TRCP1_1	349:354	DSGALT	BTRC	0.9823	More...
Q6ZRN7	Putative uncharacterized protein FLJ46214	DEG_SCF_TRCP1_1	26:31	DSGALT	BTRC	0.9455	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons