DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
LTPPQT
Uniprot ID:
Q9BYH8
Source protein:
NF-kappa-B inhibitor zeta
Source gene:
NFKBIZ
Class:
DEG_SCF_FBW7_1
Location:
188:193
E3 ligase:
FBXW7
DEGRON score:
0.9925
ASA_SCORE:
72.3167
COIL:
0.8997
CONS_SCORE:
0.5366
DSS_SCORE:
0.758
HELIX:
0.016
FCONS_SCORE:
1.2584
RIG_SCORE:
0.601
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R179G
TCGA-55-7281
LUAD
TCGA
LTPPQT
DEG_SCF_FBW7_1
0.0833
p.R179G
DO25985
LUAD
ICGC
LTPPQT
DEG_SCF_FBW7_1
0.0833
p.A181V
TCGA-A5-A0G1
UCEC
TCGA
LTPPQT
DEG_SCF_FBW7_1
0.1389
p.A181V
DO42472
UCEC
ICGC
LTPPQT
DEG_SCF_FBW7_1
0.1389
p.F187L
TCGA-AA-3510
COAD
TCGA
LTPPQT
DEG_SCF_FBW7_1
0.3056
p.F187L
DO7783
COAD
ICGC
LTPPQT
DEG_SCF_FBW7_1
0.3056
p.Q186H
DO227816
COCA
ICGC
LTPPQT
DEG_SCF_FBW7_1
0.2778
p.P180S
DO232025
LICA
ICGC
LTPPQT
DEG_SCF_FBW7_1
0.1111
p.Q192E
SIDM00892
Breast Carcinoma
GDSC
LTPPQT
DEG_SCF_FBW7_1
0.5633
p.Q192E
ACH-000818
Breast Cancer
CCLE
LTPPQT
DEG_SCF_FBW7_1
0.5633
p.Q192E
BT-483
breast
COSMIC
LTPPQT
DEG_SCF_FBW7_1
0.5633
p.S185F
HuCCT1
biliary_tract
COSMIC
LTPPQT
DEG_SCF_FBW7_1
0.25
Drug responses associated with NFKBIZ mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LTPPQT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9BYH8
NF-kappa-B inhibitor zeta
DEG_SCF_FBW7_1
188:193
LTPPQT
FBXW7
0.9925
More...