DegronMD

Uniprot ID: Q9BYH8

Source protein: NF-kappa-B inhibitor zeta

Source gene: NFKBIZ

Class: DEG_SCF_FBW7_1

Location: 188:193

E3 ligase: FBXW7

DEGRON score: 0.9925

ASA_SCORE: 72.3167

COIL: 0.8997

CONS_SCORE: 0.5366

DSS_SCORE: 0.758

HELIX: 0.016

FCONS_SCORE: 1.2584

RIG_SCORE: 0.601

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q192E	SIDM00892	Breast Carcinoma	GDSC	LTPPQT	DEG_SCF_FBW7_1	0.5633
p.Q192E	ACH-000818	Breast Cancer	CCLE	LTPPQT	DEG_SCF_FBW7_1	0.5633
p.Q192E	BT-483	breast	COSMIC	LTPPQT	DEG_SCF_FBW7_1	0.5633
p.F187L	TCGA-AA-3510	COAD	TCGA	LTPPQT	DEG_SCF_FBW7_1	0.3056
p.F187L	DO7783	COAD	ICGC	LTPPQT	DEG_SCF_FBW7_1	0.3056
p.Q186H	DO227816	COCA	ICGC	LTPPQT	DEG_SCF_FBW7_1	0.2778
p.S185F	HuCCT1	biliary_tract	COSMIC	LTPPQT	DEG_SCF_FBW7_1	0.25
p.A181V	TCGA-A5-A0G1	UCEC	TCGA	LTPPQT	DEG_SCF_FBW7_1	0.1389
p.A181V	DO42472	UCEC	ICGC	LTPPQT	DEG_SCF_FBW7_1	0.1389
p.P180S	DO232025	LICA	ICGC	LTPPQT	DEG_SCF_FBW7_1	0.1111
p.R179G	TCGA-55-7281	LUAD	TCGA	LTPPQT	DEG_SCF_FBW7_1	0.0833
p.R179G	DO25985	LUAD	ICGC	LTPPQT	DEG_SCF_FBW7_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BYH8	NF-kappa-B inhibitor zeta	DEG_SCF_FBW7_1	188:193	LTPPQT	FBXW7	0.9925	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons