DegronMD - Q9BYH8(NFKBIZ)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R179G	TCGA-55-7281	LUAD	TCGA	LTPPQT	DEG_SCF_FBW7_1	188:193	Mutation rewiring degron network	0.0833
p.R179G	DO25985	LUAD	ICGC	LTPPQT	DEG_SCF_FBW7_1	188:193	Mutation rewiring degron network	0.0833
p.A181V	TCGA-A5-A0G1	UCEC	TCGA	LTPPQT	DEG_SCF_FBW7_1	188:193	Mutation rewiring degron network	0.1389
p.A181V	DO42472	UCEC	ICGC	LTPPQT	DEG_SCF_FBW7_1	188:193	Mutation rewiring degron network	0.1389
p.F187L	TCGA-AA-3510	COAD	TCGA	LTPPQT	DEG_SCF_FBW7_1	188:193	Mutation rewiring degron network	0.3056
p.F187L	TCGA-AA-3510	COAD	TCGA	PTPGES	DEG_SCF_FBW7_1	194:199	Mutation rewiring degron network	0.1389
p.F187L	DO7783	COAD	ICGC	LTPPQT	DEG_SCF_FBW7_1	188:193	Mutation rewiring degron network	0.3056
p.F187L	DO7783	COAD	ICGC	PTPGES	DEG_SCF_FBW7_1	194:199	Mutation rewiring degron network	0.1389
p.P194Q	TCGA-AX-A063	UCEC	TCGA	PTPGES	DEG_SCF_FBW7_1	194:199	Mutation altering degron motif	0.7035
p.P194Q	DO42201	UCEC	ICGC	PTPGES	DEG_SCF_FBW7_1	194:199	Mutation altering degron motif	0.7035
p.G197R	TCGA-CV-7568	HNSC	TCGA	PTPGES	DEG_SCF_FBW7_1	194:199	Mutation altering degron motif	0.6457
p.G197R	DO14160	HNSC	ICGC	PTPGES	DEG_SCF_FBW7_1	194:199	Mutation altering degron motif	0.6457
p.G197E	TCGA-CV-7568	HNSC	TCGA	PTPGES	DEG_SCF_FBW7_1	194:199	Mutation altering degron motif	0.6087
p.G197E	DO14160	HNSC	ICGC	PTPGES	DEG_SCF_FBW7_1	194:199	Mutation altering degron motif	0.6087
p.S199N	TCGA-DF-A2KV	UCEC	TCGA	PTPGES	DEG_SCF_FBW7_1	194:199	Mutation altering degron motif	0.7069
p.S199N	DO219771	UCEC	ICGC	PTPGES	DEG_SCF_FBW7_1	194:199	Mutation altering degron motif	0.7069
p.H204L	TCGA-DK-A6AW	BLCA	TCGA	PTPGES	DEG_SCF_FBW7_1	194:199	Mutation rewiring degron network	0.1944
p.H204L	DO48566	BLCA	ICGC	PTPGES	DEG_SCF_FBW7_1	194:199	Mutation rewiring degron network	0.1944
p.N206K	TCGA-FV-A496	LIHC	TCGA	PTPGES	DEG_SCF_FBW7_1	194:199	Mutation rewiring degron network	0.1389
p.N206K	DO44966	LIHC	ICGC	PTPGES	DEG_SCF_FBW7_1	194:199	Mutation rewiring degron network	0.1389
p.Q186H	DO227816	COCA	ICGC	LTPPQT	DEG_SCF_FBW7_1	188:193	Mutation rewiring degron network	0.2778
p.Q186H	DO227816	COCA	ICGC	PTPGES	DEG_SCF_FBW7_1	194:199	Mutation rewiring degron network	0.1111
p.P208T	DO223054	ESCA	ICGC	PTPGES	DEG_SCF_FBW7_1	194:199	Mutation rewiring degron network	0.0833
p.N206S	DO228284	LICA	ICGC	PTPGES	DEG_SCF_FBW7_1	194:199	Mutation rewiring degron network	0.1389
p.P180S	DO232025	LICA	ICGC	LTPPQT	DEG_SCF_FBW7_1	188:193	Mutation rewiring degron network	0.1111
p.P208H	DO232037	ORCA	ICGC	PTPGES	DEG_SCF_FBW7_1	194:199	Mutation rewiring degron network	0.0833
p.Q192E	SIDM00892	Breast Carcinoma	GDSC	LTPPQT	DEG_SCF_FBW7_1	188:193	Mutation altering degron motif	0.5633
p.Q192E	ACH-000818	Breast Cancer	CCLE	LTPPQT	DEG_SCF_FBW7_1	188:193	Mutation altering degron motif	0.5633
p.Q192E	BT-483	breast	COSMIC	LTPPQT	DEG_SCF_FBW7_1	188:193	Mutation altering degron motif	0.5633
p.S185F	HuCCT1	biliary tract	COSMIC	LTPPQT	DEG_SCF_FBW7_1	188:193	Mutation rewiring degron network	0.25
p.S185F	HuCCT1	biliary tract	COSMIC	PTPGES	DEG_SCF_FBW7_1	194:199	Mutation rewiring degron network	0.0833

Kaplan plot for NFKBIZ in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NFKBIZ

UniProt ID: Q9BYH8

Entrez ID: 64332

Protein name: NF-kappa-B inhibitor zeta (I-kappa-B-zeta) (IkB-zeta) (IkappaBzeta) (IL-1 inducible nuclear ankyrin-repeat protein) (INAP) (Molecule possessing ankyrin repeats induced by lipopolysaccharide) (MAIL)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NFKBIZ in