DegronMD

Uniprot ID: Q9BYH8

Source protein: NF-kappa-B inhibitor zeta

Source gene: NFKBIZ

Class: DEG_SCF_FBW7_1

Location: 194:199

E3 ligase: FBXW7

DEGRON score: 0.9307

ASA_SCORE: 66.0167

COIL: 0.9353

CONS_SCORE: 0.4668

DSS_SCORE: 0.7548

HELIX: 0.0298

FCONS_SCORE: 1.0227

RIG_SCORE: 0.5672

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S199N	TCGA-DF-A2KV	UCEC	TCGA	PTPGES	DEG_SCF_FBW7_1	0.7069
p.S199N	DO219771	UCEC	ICGC	PTPGES	DEG_SCF_FBW7_1	0.7069
p.P194Q	TCGA-AX-A063	UCEC	TCGA	PTPGES	DEG_SCF_FBW7_1	0.7035
p.P194Q	DO42201	UCEC	ICGC	PTPGES	DEG_SCF_FBW7_1	0.7035
p.G197R	TCGA-CV-7568	HNSC	TCGA	PTPGES	DEG_SCF_FBW7_1	0.6457
p.G197R	DO14160	HNSC	ICGC	PTPGES	DEG_SCF_FBW7_1	0.6457
p.G197E	TCGA-CV-7568	HNSC	TCGA	PTPGES	DEG_SCF_FBW7_1	0.6087
p.G197E	DO14160	HNSC	ICGC	PTPGES	DEG_SCF_FBW7_1	0.6087
p.H204L	TCGA-DK-A6AW	BLCA	TCGA	PTPGES	DEG_SCF_FBW7_1	0.1944
p.H204L	DO48566	BLCA	ICGC	PTPGES	DEG_SCF_FBW7_1	0.1944
p.F187L	TCGA-AA-3510	COAD	TCGA	PTPGES	DEG_SCF_FBW7_1	0.1389
p.F187L	DO7783	COAD	ICGC	PTPGES	DEG_SCF_FBW7_1	0.1389
p.N206K	TCGA-FV-A496	LIHC	TCGA	PTPGES	DEG_SCF_FBW7_1	0.1389
p.N206K	DO44966	LIHC	ICGC	PTPGES	DEG_SCF_FBW7_1	0.1389
p.N206S	DO228284	LICA	ICGC	PTPGES	DEG_SCF_FBW7_1	0.1389
p.Q186H	DO227816	COCA	ICGC	PTPGES	DEG_SCF_FBW7_1	0.1111
p.P208T	DO223054	ESCA	ICGC	PTPGES	DEG_SCF_FBW7_1	0.0833
p.P208H	DO232037	ORCA	ICGC	PTPGES	DEG_SCF_FBW7_1	0.0833
p.S185F	HuCCT1	biliary_tract	COSMIC	PTPGES	DEG_SCF_FBW7_1	0.0833

Showing 1 to 19 of 19 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BYH8	NF-kappa-B inhibitor zeta	DEG_SCF_FBW7_1	194:199	PTPGES	FBXW7	0.9307	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons