DegronMD

Uniprot ID: Q86VZ6

Source protein: Juxtaposed with another zinc finger protein 1

Source gene: JAZF1

Class: DEG_SCF_FBW7_1

Location: 108:113

E3 ligase: FBXW7

DEGRON score: 0.9169

ASA_SCORE: 93.1167

COIL: 0.9755

CONS_SCORE: 0.3815

DSS_SCORE: 0.7323

HELIX: 0.0072

FCONS_SCORE: 0.9275

RIG_SCORE: 0.5702

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R102H	TCGA-AP-A051	UCEC	TCGA	LTPPVT	DEG_SCF_FBW7_1	0.1667
p.R102H	TCGA-AZ-6601	COAD	TCGA	LTPPVT	DEG_SCF_FBW7_1	0.1667
p.R102H	DO8119	COAD	ICGC	LTPPVT	DEG_SCF_FBW7_1	0.1667
p.R102H	DO42673	UCEC	ICGC	LTPPVT	DEG_SCF_FBW7_1	0.1667
p.R123C	TCGA-AP-A1DV	UCEC	TCGA	LTPPVT	DEG_SCF_FBW7_1	0.0556
p.R123C	DO43186	UCEC	ICGC	LTPPVT	DEG_SCF_FBW7_1	0.0556
p.R123H	TCGA-B7-5816	STAD	TCGA	LTPPVT	DEG_SCF_FBW7_1	0.0556
p.R123H	DO233088	GACA	ICGC	LTPPVT	DEG_SCF_FBW7_1	0.0556
p.R123H	DO38599	STAD	ICGC	LTPPVT	DEG_SCF_FBW7_1	0.0556
p.R102C	TCGA-D1-A17B	UCEC	TCGA	LTPPVT	DEG_SCF_FBW7_1	0.1667
p.R102C	DO43017	UCEC	ICGC	LTPPVT	DEG_SCF_FBW7_1	0.1667
p.R102C	SIDM00680	Colorectal Carcinoma	GDSC	LTPPVT	DEG_SCF_FBW7_1	0.1667
p.R102C	ACH-000957	Colon/Colorectal Cancer	CCLE	LTPPVT	DEG_SCF_FBW7_1	0.1667
p.R102C	LS-180	large_intestine	COSMIC	LTPPVT	DEG_SCF_FBW7_1	0.1667
p.P110L	DO220899	MELA	ICGC	LTPPVT	DEG_SCF_FBW7_1	0.7582
p.P110L	DO220906	MELA	ICGC	LTPPVT	DEG_SCF_FBW7_1	0.7582
p.P111H	DO229275	THCA	ICGC	LTPPVT	DEG_SCF_FBW7_1	0.6583
p.S107R	DO229542	UTCA	ICGC	LTPPVT	DEG_SCF_FBW7_1	0.3056
p.H103R	SIDM01090	Colorectal Carcinoma	GDSC	LTPPVT	DEG_SCF_FBW7_1	0.1944
p.H103R	ACH-000943	Colon/Colorectal Cancer	CCLE	LTPPVT	DEG_SCF_FBW7_1	0.1944
p.H103R	RKO	large_intestine	COSMIC	LTPPVT	DEG_SCF_FBW7_1	0.1944
p.R123S	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPPVT	DEG_SCF_FBW7_1	0.0556
p.R123S	ACH-002062	Lymphoma	CCLE	LTPPVT	DEG_SCF_FBW7_1	0.0556
p.R123S	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	LTPPVT	DEG_SCF_FBW7_1	0.0556
p.L108P	SIDM01608	Endometrial Carcinoma	GDSC	LTPPVT	DEG_SCF_FBW7_1	0.6471
p.L108P	ACH-000990	Endometrial/Uterine Cancer	CCLE	LTPPVT	DEG_SCF_FBW7_1	0.6471
p.S104I	ACH-001061	Colon/Colorectal Cancer	CCLE	LTPPVT	DEG_SCF_FBW7_1	0.2222
p.P111S	ACH-001547	Lung Cancer	CCLE	LTPPVT	DEG_SCF_FBW7_1	0.5641

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPPVT

Degron related mutations and impact score

Drug responses associated with JAZF1 mutations

All proteins holding degron of LTPPVT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86VZ6	Juxtaposed with another zinc finger protein 1	DEG_SCF_FBW7_1	108:113	LTPPVT	FBXW7	0.9169	More...