DegronMD - Q86VZ6(JAZF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R102H	TCGA-AP-A051	UCEC	TCGA	LTPPVT	DEG_SCF_FBW7_1	108:113	Mutation rewiring degron network	0.1667
p.R102H	TCGA-AZ-6601	COAD	TCGA	LTPPVT	DEG_SCF_FBW7_1	108:113	Mutation rewiring degron network	0.1667
p.R102H	DO8119	COAD	ICGC	LTPPVT	DEG_SCF_FBW7_1	108:113	Mutation rewiring degron network	0.1667
p.R102H	DO42673	UCEC	ICGC	LTPPVT	DEG_SCF_FBW7_1	108:113	Mutation rewiring degron network	0.1667
p.R123C	TCGA-AP-A1DV	UCEC	TCGA	LTPPVT	DEG_SCF_FBW7_1	108:113	Mutation rewiring degron network	0.0556
p.R123C	TCGA-AP-A1DV	UCEC	TCGA	PPITPSSS	DEG_SCF_FBW7_1	114:121	Mutation rewiring degron network	0.2778
p.R123C	DO43186	UCEC	ICGC	LTPPVT	DEG_SCF_FBW7_1	108:113	Mutation rewiring degron network	0.0556
p.R123C	DO43186	UCEC	ICGC	PPITPSSS	DEG_SCF_FBW7_1	114:121	Mutation rewiring degron network	0.2778
p.R123H	TCGA-B7-5816	STAD	TCGA	LTPPVT	DEG_SCF_FBW7_1	108:113	Mutation rewiring degron network	0.0556
p.R123H	TCGA-B7-5816	STAD	TCGA	PPITPSSS	DEG_SCF_FBW7_1	114:121	Mutation rewiring degron network	0.2778
p.R123H	DO233088	GACA	ICGC	LTPPVT	DEG_SCF_FBW7_1	108:113	Mutation rewiring degron network	0.0556
p.R123H	DO233088	GACA	ICGC	PPITPSSS	DEG_SCF_FBW7_1	114:121	Mutation rewiring degron network	0.2778
p.R123H	DO38599	STAD	ICGC	LTPPVT	DEG_SCF_FBW7_1	108:113	Mutation rewiring degron network	0.0556
p.R123H	DO38599	STAD	ICGC	PPITPSSS	DEG_SCF_FBW7_1	114:121	Mutation rewiring degron network	0.2778
p.R102C	TCGA-D1-A17B	UCEC	TCGA	LTPPVT	DEG_SCF_FBW7_1	108:113	Mutation rewiring degron network	0.1667
p.R102C	DO43017	UCEC	ICGC	LTPPVT	DEG_SCF_FBW7_1	108:113	Mutation rewiring degron network	0.1667
p.R102C	SIDM00680	Colorectal Carcinoma	GDSC	LTPPVT	DEG_SCF_FBW7_1	108:113	Mutation rewiring degron network	0.1667
p.R102C	ACH-000957	Colon/Colorectal Cancer	CCLE	LTPPVT	DEG_SCF_FBW7_1	108:113	Mutation rewiring degron network	0.1667
p.R102C	LS-180	large intestine	COSMIC	LTPPVT	DEG_SCF_FBW7_1	108:113	Mutation rewiring degron network	0.1667
p.P127L	TCGA-EB-A5UN	SKCM	TCGA	PPITPSSS	DEG_SCF_FBW7_1	114:121	Mutation rewiring degron network	0.1667
p.P127L	DO47267	SKCM	ICGC	PPITPSSS	DEG_SCF_FBW7_1	114:121	Mutation rewiring degron network	0.1667
p.T126A	DO233005	GACA	ICGC	PPITPSSS	DEG_SCF_FBW7_1	114:121	Mutation rewiring degron network	0.1944
p.P115H	DO229027	LICA	ICGC	PPITPSSS	DEG_SCF_FBW7_1	114:121	Mutation altering degron motif	0.6583
p.P114Q	DO229032	LICA	ICGC	PPITPSSS	DEG_SCF_FBW7_1	114:121	Mutation altering degron motif	0.7035
p.P110L	DO220899	MELA	ICGC	LTPPVT	DEG_SCF_FBW7_1	108:113	Mutation altering degron motif	0.7582
p.P110L	DO220906	MELA	ICGC	LTPPVT	DEG_SCF_FBW7_1	108:113	Mutation altering degron motif	0.7582
p.P118L	DO34720	PACA	ICGC	PPITPSSS	DEG_SCF_FBW7_1	114:121	Mutation altering degron motif	0.7582
p.P111H	DO229275	THCA	ICGC	LTPPVT	DEG_SCF_FBW7_1	108:113	Mutation altering degron motif	0.6583
p.T117A	DO229213	THCA	ICGC	PPITPSSS	DEG_SCF_FBW7_1	114:121	Mutation altering degron motif	0.825
p.S107R	DO229542	UTCA	ICGC	LTPPVT	DEG_SCF_FBW7_1	108:113	Mutation rewiring degron network	0.3056
p.S107R	DO229542	UTCA	ICGC	PPITPSSS	DEG_SCF_FBW7_1	114:121	Mutation rewiring degron network	0.1389
p.H103R	SIDM01090	Colorectal Carcinoma	GDSC	LTPPVT	DEG_SCF_FBW7_1	108:113	Mutation rewiring degron network	0.1944
p.H103R	ACH-000943	Colon/Colorectal Cancer	CCLE	LTPPVT	DEG_SCF_FBW7_1	108:113	Mutation rewiring degron network	0.1944
p.H103R	RKO	large intestine	COSMIC	LTPPVT	DEG_SCF_FBW7_1	108:113	Mutation rewiring degron network	0.1944
p.R123S	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPPVT	DEG_SCF_FBW7_1	108:113	Mutation rewiring degron network	0.0556
p.R123S	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPITPSSS	DEG_SCF_FBW7_1	114:121	Mutation rewiring degron network	0.2778
p.R123S	ACH-002062	Lymphoma	CCLE	LTPPVT	DEG_SCF_FBW7_1	108:113	Mutation rewiring degron network	0.0556
p.R123S	ACH-002062	Lymphoma	CCLE	PPITPSSS	DEG_SCF_FBW7_1	114:121	Mutation rewiring degron network	0.2778
p.R123S	SLVL	haematopoietic and lymphoid tissue	COSMIC	LTPPVT	DEG_SCF_FBW7_1	108:113	Mutation rewiring degron network	0.0556
p.R123S	SLVL	haematopoietic and lymphoid tissue	COSMIC	PPITPSSS	DEG_SCF_FBW7_1	114:121	Mutation rewiring degron network	0.2778
p.T117I	SIDM01060	Melanoma	GDSC	PPITPSSS	DEG_SCF_FBW7_1	114:121	Mutation altering degron motif	0.8189
p.T117I	ACH-000882	Skin Cancer	CCLE	PPITPSSS	DEG_SCF_FBW7_1	114:121	Mutation altering degron motif	0.8189
p.T117I	IGR-1	skin	COSMIC	PPITPSSS	DEG_SCF_FBW7_1	114:121	Mutation altering degron motif	0.8189
p.L108P	SIDM01608	Endometrial Carcinoma	GDSC	LTPPVT	DEG_SCF_FBW7_1	108:113	Mutation altering degron motif	0.6471
p.L108P	ACH-000990	Endometrial/Uterine Cancer	CCLE	LTPPVT	DEG_SCF_FBW7_1	108:113	Mutation altering degron motif	0.6471
p.S104I	ACH-001061	Colon/Colorectal Cancer	CCLE	LTPPVT	DEG_SCF_FBW7_1	108:113	Mutation rewiring degron network	0.2222
p.S104I	ACH-001061	Colon/Colorectal Cancer	CCLE	PPITPSSS	DEG_SCF_FBW7_1	114:121	Mutation rewiring degron network	0.0556
p.P111S	ACH-001547	Lung Cancer	CCLE	LTPPVT	DEG_SCF_FBW7_1	108:113	Mutation altering degron motif	0.5641

Kaplan plot for JAZF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

JAZF1

UniProt ID: Q86VZ6

Entrez ID: 221895

Protein name: Juxtaposed with another zinc finger protein 1 (TAK1-interacting protein 27) (Zinc finger protein 802)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for JAZF1 in