DegronMD

Uniprot ID: Q86VZ6

Source protein: Juxtaposed with another zinc finger protein 1

Source gene: JAZF1

Class: DEG_SCF_FBW7_1

Location: 114:121

E3 ligase: FBXW7

DEGRON score: 0.9105

ASA_SCORE: 85.9875

COIL: 0.9315

CONS_SCORE: 0.394

DSS_SCORE: 0.6776

HELIX: 0.0378

FCONS_SCORE: 0.9546

RIG_SCORE: 0.5919

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R123C	TCGA-AP-A1DV	UCEC	TCGA	PPITPSSS	DEG_SCF_FBW7_1	0.2778
p.R123C	DO43186	UCEC	ICGC	PPITPSSS	DEG_SCF_FBW7_1	0.2778
p.R123H	TCGA-B7-5816	STAD	TCGA	PPITPSSS	DEG_SCF_FBW7_1	0.2778
p.R123H	DO233088	GACA	ICGC	PPITPSSS	DEG_SCF_FBW7_1	0.2778
p.R123H	DO38599	STAD	ICGC	PPITPSSS	DEG_SCF_FBW7_1	0.2778
p.P127L	TCGA-EB-A5UN	SKCM	TCGA	PPITPSSS	DEG_SCF_FBW7_1	0.1667
p.P127L	DO47267	SKCM	ICGC	PPITPSSS	DEG_SCF_FBW7_1	0.1667
p.T126A	DO233005	GACA	ICGC	PPITPSSS	DEG_SCF_FBW7_1	0.1944
p.P115H	DO229027	LICA	ICGC	PPITPSSS	DEG_SCF_FBW7_1	0.6583
p.P114Q	DO229032	LICA	ICGC	PPITPSSS	DEG_SCF_FBW7_1	0.7035
p.P118L	DO34720	PACA	ICGC	PPITPSSS	DEG_SCF_FBW7_1	0.7582
p.T117A	DO229213	THCA	ICGC	PPITPSSS	DEG_SCF_FBW7_1	0.825
p.S107R	DO229542	UTCA	ICGC	PPITPSSS	DEG_SCF_FBW7_1	0.1389
p.R123S	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPITPSSS	DEG_SCF_FBW7_1	0.2778
p.R123S	ACH-002062	Lymphoma	CCLE	PPITPSSS	DEG_SCF_FBW7_1	0.2778
p.R123S	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	PPITPSSS	DEG_SCF_FBW7_1	0.2778
p.T117I	SIDM01060	Melanoma	GDSC	PPITPSSS	DEG_SCF_FBW7_1	0.8189
p.T117I	ACH-000882	Skin Cancer	CCLE	PPITPSSS	DEG_SCF_FBW7_1	0.8189
p.T117I	IGR-1	skin	COSMIC	PPITPSSS	DEG_SCF_FBW7_1	0.8189
p.S104I	ACH-001061	Colon/Colorectal Cancer	CCLE	PPITPSSS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86VZ6	Juxtaposed with another zinc finger protein 1	DEG_SCF_FBW7_1	114:121	PPITPSSS	FBXW7	0.9105	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons