DegronMD

Uniprot ID: P10646

Source protein: Tissue factor pathway inhibitor

Source gene: TFPI

Class: DEG_SCF_FBW7_1

Location: 198:203

E3 ligase: FBXW7

DEGRON score: 0.9653

ASA_SCORE: 80.1

COIL: 0.8767

CONS_SCORE: 0.5993

DSS_SCORE: 0.3647

HELIX: 0.0753

FCONS_SCORE: 1.1089

RIG_SCORE: 0.7334

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T199I	TCGA-55-8097	LUAD	TCGA	LTPQST	DEG_SCF_FBW7_1	0.7078
p.T199I	DO25699	LUAD	ICGC	LTPQST	DEG_SCF_FBW7_1	0.7078
p.L191F	TCGA-AP-A1DK	UCEC	TCGA	LTPQST	DEG_SCF_FBW7_1	0.1389
p.L191F	DO42033	UCEC	ICGC	LTPQST	DEG_SCF_FBW7_1	0.1389
p.H212Q	TCGA-CG-4442	STAD	TCGA	LTPQST	DEG_SCF_FBW7_1	0.0833
p.H212Q	DO38380	STAD	ICGC	LTPQST	DEG_SCF_FBW7_1	0.0833
p.G213S	TCGA-D8-A1Y1	BRCA	TCGA	LTPQST	DEG_SCF_FBW7_1	0.0556
p.G213S	DO1398	BRCA	ICGC	LTPQST	DEG_SCF_FBW7_1	0.0556
p.N195K	TCGA-LN-A4A3	ESCA	TCGA	LTPQST	DEG_SCF_FBW7_1	0.25
p.Q201H	TCGA-PK-A5HB	ACC	TCGA	LTPQST	DEG_SCF_FBW7_1	0.647
p.K212E	DO51692	PAAD	ICGC	LTPQST	DEG_SCF_FBW7_1	0.0833
p.L198P	DO232675	PBCA	ICGC	LTPQST	DEG_SCF_FBW7_1	0.6471
p.V194M	SIDM00535	Chondrosarcoma	GDSC	LTPQST	DEG_SCF_FBW7_1	0.2222
p.V194M	SIDM00618	Hepatocellular Carcinoma	GDSC	LTPQST	DEG_SCF_FBW7_1	0.2222
p.V194M	H-EMC-SS	bone	COSMIC	LTPQST	DEG_SCF_FBW7_1	0.2222
p.V194M	JHH-1	liver	COSMIC	LTPQST	DEG_SCF_FBW7_1	0.2222
p.G188E	SIDM00973	Melanoma	GDSC	LTPQST	DEG_SCF_FBW7_1	0.0556
p.G188E	ACH-000827	Skin Cancer	CCLE	LTPQST	DEG_SCF_FBW7_1	0.0556
p.G188E	WM793B	skin	COSMIC	LTPQST	DEG_SCF_FBW7_1	0.0556
p.F209S	SIDM00118	Colorectal Carcinoma	GDSC	LTPQST	DEG_SCF_FBW7_1	0.1667
p.F209S	ACH-001081	Colon/Colorectal Cancer	CCLE	LTPQST	DEG_SCF_FBW7_1	0.1667
p.F209S	HCC2998	large_intestine	COSMIC	LTPQST	DEG_SCF_FBW7_1	0.1667
p.S202L	SIDM01776	Plasma Cell Myeloma	GDSC	LTPQST	DEG_SCF_FBW7_1	0.6556
p.S202L	ACH-001162	Myeloma	CCLE	LTPQST	DEG_SCF_FBW7_1	0.6556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10646	Tissue factor pathway inhibitor	DEG_SCF_FBW7_1	198:203	LTPQST	FBXW7	0.9653	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons