DegronMD - P10646(TFPI)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T199I	TCGA-55-8097	LUAD	TCGA	TPQSTKVPSL	DEG_COP1_1	199:208	Mutation altering degron motif	0.7078
p.T199I	TCGA-55-8097	LUAD	TCGA	LTPQST	DEG_SCF_FBW7_1	198:203	Mutation altering degron motif	0.7078
p.T199I	DO25699	LUAD	ICGC	TPQSTKVPSL	DEG_COP1_1	199:208	Mutation altering degron motif	0.7078
p.T199I	DO25699	LUAD	ICGC	LTPQST	DEG_SCF_FBW7_1	198:203	Mutation altering degron motif	0.7078
p.L191F	TCGA-AP-A1DK	UCEC	TCGA	TPQSTKVPSL	DEG_COP1_1	199:208	Mutation rewiring degron network	0.1111
p.L191F	TCGA-AP-A1DK	UCEC	TCGA	LTPQST	DEG_SCF_FBW7_1	198:203	Mutation rewiring degron network	0.1389
p.L191F	DO42033	UCEC	ICGC	TPQSTKVPSL	DEG_COP1_1	199:208	Mutation rewiring degron network	0.1111
p.L191F	DO42033	UCEC	ICGC	LTPQST	DEG_SCF_FBW7_1	198:203	Mutation rewiring degron network	0.1389
p.H212Q	TCGA-CG-4442	STAD	TCGA	TPQSTKVPSL	DEG_COP1_1	199:208	Mutation rewiring degron network	0.2222
p.H212Q	TCGA-CG-4442	STAD	TCGA	LTPQST	DEG_SCF_FBW7_1	198:203	Mutation rewiring degron network	0.0833
p.H212Q	DO38380	STAD	ICGC	TPQSTKVPSL	DEG_COP1_1	199:208	Mutation rewiring degron network	0.2222
p.H212Q	DO38380	STAD	ICGC	LTPQST	DEG_SCF_FBW7_1	198:203	Mutation rewiring degron network	0.0833
p.K204M	TCGA-D7-6820	STAD	TCGA	TPQSTKVPSL	DEG_COP1_1	199:208	Mutation altering degron motif	0.6951
p.K204M	DO38531	STAD	ICGC	TPQSTKVPSL	DEG_COP1_1	199:208	Mutation altering degron motif	0.6951
p.G213S	TCGA-D8-A1Y1	BRCA	TCGA	TPQSTKVPSL	DEG_COP1_1	199:208	Mutation rewiring degron network	0.1944
p.G213S	TCGA-D8-A1Y1	BRCA	TCGA	LTPQST	DEG_SCF_FBW7_1	198:203	Mutation rewiring degron network	0.0556
p.G213S	DO1398	BRCA	ICGC	TPQSTKVPSL	DEG_COP1_1	199:208	Mutation rewiring degron network	0.1944
p.G213S	DO1398	BRCA	ICGC	LTPQST	DEG_SCF_FBW7_1	198:203	Mutation rewiring degron network	0.0556
p.N195K	TCGA-LN-A4A3	ESCA	TCGA	TPQSTKVPSL	DEG_COP1_1	199:208	Mutation rewiring degron network	0.2222
p.N195K	TCGA-LN-A4A3	ESCA	TCGA	LTPQST	DEG_SCF_FBW7_1	198:203	Mutation rewiring degron network	0.25
p.Q201H	TCGA-PK-A5HB	ACC	TCGA	TPQSTKVPSL	DEG_COP1_1	199:208	Mutation altering degron motif	0.647
p.Q201H	TCGA-PK-A5HB	ACC	TCGA	LTPQST	DEG_SCF_FBW7_1	198:203	Mutation altering degron motif	0.647
p.P206L	DO220877	MELA	ICGC	TPQSTKVPSL	DEG_COP1_1	199:208	Mutation altering degron motif	0.7582
p.K212E	DO51692	PAAD	ICGC	TPQSTKVPSL	DEG_COP1_1	199:208	Mutation rewiring degron network	0.2222
p.K212E	DO51692	PAAD	ICGC	LTPQST	DEG_SCF_FBW7_1	198:203	Mutation rewiring degron network	0.0833
p.L198P	DO232675	PBCA	ICGC	LTPQST	DEG_SCF_FBW7_1	198:203	Mutation altering degron motif	0.6471
p.V194M	SIDM00535	Chondrosarcoma	GDSC	TPQSTKVPSL	DEG_COP1_1	199:208	Mutation rewiring degron network	0.1944
p.V194M	SIDM00535	Chondrosarcoma	GDSC	LTPQST	DEG_SCF_FBW7_1	198:203	Mutation rewiring degron network	0.2222
p.V194M	SIDM00618	Hepatocellular Carcinoma	GDSC	TPQSTKVPSL	DEG_COP1_1	199:208	Mutation rewiring degron network	0.1944
p.V194M	SIDM00618	Hepatocellular Carcinoma	GDSC	LTPQST	DEG_SCF_FBW7_1	198:203	Mutation rewiring degron network	0.2222
p.V194M	H-EMC-SS	bone	COSMIC	TPQSTKVPSL	DEG_COP1_1	199:208	Mutation rewiring degron network	0.1944
p.V194M	H-EMC-SS	bone	COSMIC	LTPQST	DEG_SCF_FBW7_1	198:203	Mutation rewiring degron network	0.2222
p.V194M	JHH-1	liver	COSMIC	TPQSTKVPSL	DEG_COP1_1	199:208	Mutation rewiring degron network	0.1944
p.V194M	JHH-1	liver	COSMIC	LTPQST	DEG_SCF_FBW7_1	198:203	Mutation rewiring degron network	0.2222
p.G188E	SIDM00973	Melanoma	GDSC	LTPQST	DEG_SCF_FBW7_1	198:203	Mutation rewiring degron network	0.0556
p.G188E	ACH-000827	Skin Cancer	CCLE	LTPQST	DEG_SCF_FBW7_1	198:203	Mutation rewiring degron network	0.0556
p.G188E	WM793B	skin	COSMIC	LTPQST	DEG_SCF_FBW7_1	198:203	Mutation rewiring degron network	0.0556
p.F209S	SIDM00118	Colorectal Carcinoma	GDSC	TPQSTKVPSL	DEG_COP1_1	199:208	Mutation rewiring degron network	0.3056
p.F209S	SIDM00118	Colorectal Carcinoma	GDSC	LTPQST	DEG_SCF_FBW7_1	198:203	Mutation rewiring degron network	0.1667
p.F209S	ACH-001081	Colon/Colorectal Cancer	CCLE	TPQSTKVPSL	DEG_COP1_1	199:208	Mutation rewiring degron network	0.3056
p.F209S	ACH-001081	Colon/Colorectal Cancer	CCLE	LTPQST	DEG_SCF_FBW7_1	198:203	Mutation rewiring degron network	0.1667
p.F209S	HCC2998	large intestine	COSMIC	TPQSTKVPSL	DEG_COP1_1	199:208	Mutation rewiring degron network	0.3056
p.F209S	HCC2998	large intestine	COSMIC	LTPQST	DEG_SCF_FBW7_1	198:203	Mutation rewiring degron network	0.1667
p.T215K	SIDM01409	Bladder Carcinoma	GDSC	TPQSTKVPSL	DEG_COP1_1	199:208	Mutation rewiring degron network	0.1389
p.S202L	SIDM01776	Plasma Cell Myeloma	GDSC	TPQSTKVPSL	DEG_COP1_1	199:208	Mutation altering degron motif	0.7667
p.S202L	SIDM01776	Plasma Cell Myeloma	GDSC	LTPQST	DEG_SCF_FBW7_1	198:203	Mutation altering degron motif	0.6556
p.S202L	ACH-001162	Myeloma	CCLE	TPQSTKVPSL	DEG_COP1_1	199:208	Mutation altering degron motif	0.7667
p.S202L	ACH-001162	Myeloma	CCLE	LTPQST	DEG_SCF_FBW7_1	198:203	Mutation altering degron motif	0.6556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TFPI

UniProt ID: P10646

Entrez ID: 7035

Protein name: Tissue factor pathway inhibitor (TFPI) (Extrinsic pathway inhibitor) (EPI) (Lipoprotein-associated coagulation inhibitor) (LACI)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TFPI in