DegronMD

Uniprot ID: P10646

Source protein: Tissue factor pathway inhibitor

Source gene: TFPI

Class: DEG_COP1_1

Location: 199:208

E3 ligase: COP1

DEGRON score: 0.8349

ASA_SCORE: 76.68

COIL: 0.8283

CONS_SCORE: 0.5475

DSS_SCORE: 0.331

HELIX: 0.1082

FCONS_SCORE: 0.9424

RIG_SCORE: 0.746

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T199I	TCGA-55-8097	LUAD	TCGA	TPQSTKVPSL	DEG_COP1_1	0.7078
p.T199I	DO25699	LUAD	ICGC	TPQSTKVPSL	DEG_COP1_1	0.7078
p.L191F	TCGA-AP-A1DK	UCEC	TCGA	TPQSTKVPSL	DEG_COP1_1	0.1111
p.L191F	DO42033	UCEC	ICGC	TPQSTKVPSL	DEG_COP1_1	0.1111
p.H212Q	TCGA-CG-4442	STAD	TCGA	TPQSTKVPSL	DEG_COP1_1	0.2222
p.H212Q	DO38380	STAD	ICGC	TPQSTKVPSL	DEG_COP1_1	0.2222
p.K204M	TCGA-D7-6820	STAD	TCGA	TPQSTKVPSL	DEG_COP1_1	0.6951
p.K204M	DO38531	STAD	ICGC	TPQSTKVPSL	DEG_COP1_1	0.6951
p.G213S	TCGA-D8-A1Y1	BRCA	TCGA	TPQSTKVPSL	DEG_COP1_1	0.1944
p.G213S	DO1398	BRCA	ICGC	TPQSTKVPSL	DEG_COP1_1	0.1944
p.N195K	TCGA-LN-A4A3	ESCA	TCGA	TPQSTKVPSL	DEG_COP1_1	0.2222
p.Q201H	TCGA-PK-A5HB	ACC	TCGA	TPQSTKVPSL	DEG_COP1_1	0.647
p.P206L	DO220877	MELA	ICGC	TPQSTKVPSL	DEG_COP1_1	0.7582
p.K212E	DO51692	PAAD	ICGC	TPQSTKVPSL	DEG_COP1_1	0.2222
p.V194M	SIDM00535	Chondrosarcoma	GDSC	TPQSTKVPSL	DEG_COP1_1	0.1944
p.V194M	SIDM00618	Hepatocellular Carcinoma	GDSC	TPQSTKVPSL	DEG_COP1_1	0.1944
p.V194M	H-EMC-SS	bone	COSMIC	TPQSTKVPSL	DEG_COP1_1	0.1944
p.V194M	JHH-1	liver	COSMIC	TPQSTKVPSL	DEG_COP1_1	0.1944
p.F209S	SIDM00118	Colorectal Carcinoma	GDSC	TPQSTKVPSL	DEG_COP1_1	0.3056
p.F209S	ACH-001081	Colon/Colorectal Cancer	CCLE	TPQSTKVPSL	DEG_COP1_1	0.3056
p.F209S	HCC2998	large_intestine	COSMIC	TPQSTKVPSL	DEG_COP1_1	0.3056
p.T215K	SIDM01409	Bladder Carcinoma	GDSC	TPQSTKVPSL	DEG_COP1_1	0.1389
p.S202L	SIDM01776	Plasma Cell Myeloma	GDSC	TPQSTKVPSL	DEG_COP1_1	0.7667
p.S202L	ACH-001162	Myeloma	CCLE	TPQSTKVPSL	DEG_COP1_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10646	Tissue factor pathway inhibitor	DEG_COP1_1	199:208	TPQSTKVPSL	COP1	0.8349	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons