DegronMD

Uniprot ID: Q8TEM1

Source protein: Nuclear pore membrane glycoprotein 210

Source gene: NUP210

Class: DEG_SCF_FBW7_1

Location: 1843:1848

E3 ligase: FBXW7

DEGRON score: 0.8663

ASA_SCORE: 75.1

COIL: 0.9368

CONS_SCORE: 0.3153

DSS_SCORE: 0.3977

HELIX: 0.0185

FCONS_SCORE: 1.1223

RIG_SCORE: 0.6521

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1833M	TCGA-2J-AAB6	PAAD	TCGA	LTPRAS	DEG_SCF_FBW7_1	0.0556
p.T1833M	DO51656	PAAD	ICGC	LTPRAS	DEG_SCF_FBW7_1	0.0556
p.A1857T	TCGA-AX-A1CE	UCEC	TCGA	LTPRAS	DEG_SCF_FBW7_1	0.0833
p.A1857T	DO42280	UCEC	ICGC	LTPRAS	DEG_SCF_FBW7_1	0.0833
p.R1835L	TCGA-D3-A2JK	SKCM	TCGA	LTPRAS	DEG_SCF_FBW7_1	0.1111
p.R1835L	DO37619	SKCM	ICGC	LTPRAS	DEG_SCF_FBW7_1	0.1111
p.L1837R	DO233840	GACA	ICGC	LTPRAS	DEG_SCF_FBW7_1	0.1667
p.L1837R	SIDM01312	Esophageal Carcinoma	GDSC	LTPRAS	DEG_SCF_FBW7_1	0.1667
p.R1835Q	DO229036	LICA	ICGC	LTPRAS	DEG_SCF_FBW7_1	0.1111
p.R1835Q	SIDM00522	Small Cell Lung Carcinoma	GDSC	LTPRAS	DEG_SCF_FBW7_1	0.1111
p.R1835Q	DMS-273	lung	COSMIC	LTPRAS	DEG_SCF_FBW7_1	0.1111
p.P1845T	DO229045	LICA	ICGC	LTPRAS	DEG_SCF_FBW7_1	0.7031
p.T1844M	SIDM01735	Biliary Tract Carcinoma	GDSC	LTPRAS	DEG_SCF_FBW7_1	0.8534
p.R1835W	ACH-001656	Leukemia	CCLE	LTPRAS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEM1	Nuclear pore membrane glycoprotein 210	DEG_SCF_FBW7_1	1843:1848	LTPRAS	FBXW7	0.8663	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons