DegronMD

Uniprot ID: Q9GZN6

Source protein: Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

Source gene: SLC6A16

Class: DEG_SCF_FBW7_2

Location: 709:714

E3 ligase: FBXW7

DEGRON score: 0.771

ASA_SCORE: 91.6833

COIL: 0.7762

CONS_SCORE: 0.2927

DSS_SCORE: 0.5441

HELIX: 0.2102

FCONS_SCORE: 1.0986

RIG_SCORE: 0.6902

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L721I	TCGA-B5-A11N	UCEC	TCGA	LTPSKE	DEG_SCF_FBW7_2	0.1389
p.L721I	TCGA-EO-A22X	UCEC	TCGA	LTPSKE	DEG_SCF_FBW7_2	0.1389
p.L721I	DO43907	UCEC	ICGC	LTPSKE	DEG_SCF_FBW7_2	0.1389
p.L721I	DO41458	UCEC	ICGC	LTPSKE	DEG_SCF_FBW7_2	0.1389
p.E718K	TCGA-EE-A2MT	SKCM	TCGA	LTPSKE	DEG_SCF_FBW7_2	0.2222
p.E718K	DO38051	SKCM	ICGC	LTPSKE	DEG_SCF_FBW7_2	0.2222
p.P711S	TCGA-XK-AAIW	PRAD	TCGA	LTPSKE	DEG_SCF_FBW7_2	0.6752
p.P711S	DO51407	PRAD	ICGC	LTPSKE	DEG_SCF_FBW7_2	0.6752
p.V715L	DO232031	LICA	ICGC	LTPSKE	DEG_SCF_FBW7_2	0.3056
p.A699D	DO229036	LICA	ICGC	LTPSKE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9GZN6	Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5	DEG_SCF_FBW7_2	709:714	LTPSKE	FBXW7	0.771	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons