DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_1

Location: 9000:9007

E3 ligase: FBXW7

DEGRON score: 0.7373

ASA_SCORE: 103.0375

COIL: 0.9163

CONS_SCORE: 0

DSS_SCORE: 0.707

HELIX: 0.0189

FCONS_SCORE: 0

RIG_SCORE: 0.6565

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P9004A	TCGA-25-2391	OV	TCGA	LTPTPRET	DEG_SCF_FBW7_1	0.7503
p.P9004A	DO31769	OV	ICGC	LTPTPRET	DEG_SCF_FBW7_1	0.7503
p.R8991I	TCGA-A5-A2K5	UCEC	TCGA	LTPTPRET	DEG_SCF_FBW7_1	0.0833
p.R8991I	TCGA-AZ-4315	COAD	TCGA	LTPTPRET	DEG_SCF_FBW7_1	0.0833
p.R8991I	TCGA-EO-A3B0	UCEC	TCGA	LTPTPRET	DEG_SCF_FBW7_1	0.0833
p.R8991I	DO8842	COAD	ICGC	LTPTPRET	DEG_SCF_FBW7_1	0.0833
p.R8991I	DO219773	UCEC	ICGC	LTPTPRET	DEG_SCF_FBW7_1	0.0833
p.R8991I	DO41379	UCEC	ICGC	LTPTPRET	DEG_SCF_FBW7_1	0.0833
p.R8991I	SIDM00578	Neuroblastoma	GDSC	LTPTPRET	DEG_SCF_FBW7_1	0.0833
p.R8991I	ACH-000804	Neuroblastoma	CCLE	LTPTPRET	DEG_SCF_FBW7_1	0.0833
p.T8990I	TCGA-B0-4698	KIRC	TCGA	LTPTPRET	DEG_SCF_FBW7_1	0.5
p.T8990I	DO20368	KIRC	ICGC	LTPTPRET	DEG_SCF_FBW7_1	0.5
p.T9009S	TCGA-BG-A222	UCEC	TCGA	LTPTPRET	DEG_SCF_FBW7_1	0.2778
p.T9009S	DO42977	UCEC	ICGC	LTPTPRET	DEG_SCF_FBW7_1	0.2778
p.T8997A	TCGA-GN-A269	SKCM	TCGA	LTPTPRET	DEG_SCF_FBW7_1	0.25
p.T8997A	DO37483	SKCM	ICGC	LTPTPRET	DEG_SCF_FBW7_1	0.25
p.T8997K	TCGA-OR-A5K8	ACC	TCGA	LTPTPRET	DEG_SCF_FBW7_1	0.25
p.M8994I	TCGA-WE-A8K5	SKCM	TCGA	LTPTPRET	DEG_SCF_FBW7_1	0.1667
p.M8994I	DO51282	SKCM	ICGC	LTPTPRET	DEG_SCF_FBW7_1	0.1667
p.E8993Q	DO48210	ESCA	ICGC	LTPTPRET	DEG_SCF_FBW7_1	0.1389
p.T9003S	SIDM01483	Melanoma	GDSC	LTPTPRET	DEG_SCF_FBW7_1	0.7116
p.T9009A	SIDM00265	Ewing's Sarcoma	GDSC	LTPTPRET	DEG_SCF_FBW7_1	0.2778
p.T9009A	ES3	bone	COSMIC	LTPTPRET	DEG_SCF_FBW7_1	0.2778
p.E8993D	SIDM00983	Bladder Carcinoma	GDSC	LTPTPRET	DEG_SCF_FBW7_1	0.1389
p.E8993D	SIDM00254	Neuroblastoma	GDSC	LTPTPRET	DEG_SCF_FBW7_1	0.1389
p.E8993D	ACH-000896	Bladder Cancer	CCLE	LTPTPRET	DEG_SCF_FBW7_1	0.1389
p.E8993D	ACH-002283	Neuroblastoma	CCLE	LTPTPRET	DEG_SCF_FBW7_1	0.1389
p.E8993D	NB5	autonomic_ganglia	COSMIC	LTPTPRET	DEG_SCF_FBW7_1	0.1389
p.E8993D	647-V	urinary_tract	COSMIC	LTPTPRET	DEG_SCF_FBW7_1	0.1389
p.T9009N	ACH-001461	Colon/Colorectal Cancer	CCLE	LTPTPRET	DEG_SCF_FBW7_1	0.2778
p.T8999I	ACH-001982	Metastasis	CCLE	LTPTPRET	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPTPRET

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of LTPTPRET

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	9000:9007	LTPTPRET	FBXW7	0.7373	More...