DegronMD

Uniprot ID: Q8N9W8

Source protein: Golgi associated RAB2 interactor protein 2

Source gene: GARIN2

Class: DEG_SCF_FBW7_1

Location: 351:356

E3 ligase: FBXW7

DEGRON score: 0.85

ASA_SCORE: 67.5833

COIL: 0.5222

CONS_SCORE: 0.7541

DSS_SCORE: 0.5048

HELIX: 0.1363

FCONS_SCORE: 1.1652

RIG_SCORE: 0.7606

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R345T	TCGA-73-4659	LUAD	TCGA	LTPVES	DEG_SCF_FBW7_1	0.1667
p.D366N	TCGA-FR-A726	SKCM	TCGA	LTPVES	DEG_SCF_FBW7_1	0.0556
p.Q348K	TCGA-KQ-A41N	BLCA	TCGA	LTPVES	DEG_SCF_FBW7_1	0.25
p.E363K	TCGA-LN-A49Y	ESCA	TCGA	LTPVES	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N9W8	Golgi associated RAB2 interactor protein 2	DEG_SCF_FBW7_1	351:356	LTPVES	FBXW7	0.85	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons