DegronMD - Q8N9W8(GARIN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R345T	TCGA-73-4659	LUAD	TCGA	LTPVES	DEG_SCF_FBW7_1	351:356	Mutation rewiring degron network	0.1667
p.D242N	TCGA-AJ-A3OJ	UCEC	TCGA	TDLPENEVPEV	DEG_COP1_1	247:257	Mutation rewiring degron network	0.1944
p.D242N	SIDM01263	T-Lymphoblastic Leukemia	GDSC	TDLPENEVPEV	DEG_COP1_1	247:257	Mutation rewiring degron network	0.1944
p.P258L	TCGA-F4-6570	COAD	TCGA	TDLPENEVPEV	DEG_COP1_1	247:257	Mutation rewiring degron network	0.3056
p.D366N	TCGA-FR-A726	SKCM	TCGA	LTPVES	DEG_SCF_FBW7_1	351:356	Mutation rewiring degron network	0.0556
p.Q348K	TCGA-KQ-A41N	BLCA	TCGA	LTPVES	DEG_SCF_FBW7_1	351:356	Mutation rewiring degron network	0.25
p.E363K	TCGA-LN-A49Y	ESCA	TCGA	LTPVES	DEG_SCF_FBW7_1	351:356	Mutation rewiring degron network	0.1389
p.E253K	TCGA-UY-A9PF	BLCA	TCGA	TDLPENEVPEV	DEG_COP1_1	247:257	Mutation altering degron motif	0.591
p.D259N	SIDM00251	Gastric Carcinoma	GDSC	TDLPENEVPEV	DEG_COP1_1	247:257	Mutation rewiring degron network	0.2778
p.E256D	SIDM00815	Ovarian Carcinoma	GDSC	TDLPENEVPEV	DEG_COP1_1	247:257	Mutation altering degron motif	0.5647

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons