DegronMD

Uniprot ID: Q8N9W8

Source protein: Golgi associated RAB2 interactor protein 2

Source gene: GARIN2

Class: DEG_COP1_1

Location: 247:257

E3 ligase: COP1

DEGRON score: 0.995

ASA_SCORE: 77.6727

COIL: 0.7665

CONS_SCORE: 0.7191

DSS_SCORE: 0.5184

HELIX: 0.0705

FCONS_SCORE: 0.8913

RIG_SCORE: 0.7836

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E253K	TCGA-UY-A9PF	BLCA	TCGA	TDLPENEVPEV	DEG_COP1_1	0.591
p.E256D	SIDM00815	Ovarian Carcinoma	GDSC	TDLPENEVPEV	DEG_COP1_1	0.5647
p.P258L	TCGA-F4-6570	COAD	TCGA	TDLPENEVPEV	DEG_COP1_1	0.3056
p.D259N	SIDM00251	Gastric Carcinoma	GDSC	TDLPENEVPEV	DEG_COP1_1	0.2778
p.D242N	TCGA-AJ-A3OJ	UCEC	TCGA	TDLPENEVPEV	DEG_COP1_1	0.1944
p.D242N	SIDM01263	T-Lymphoblastic Leukemia	GDSC	TDLPENEVPEV	DEG_COP1_1	0.1944

Showing 1 to 6 of 6 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N9W8	Golgi associated RAB2 interactor protein 2	DEG_COP1_1	247:257	TDLPENEVPEV	COP1	0.995	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons