DegronMD

Uniprot ID: Q96QU1

Source protein: Protocadherin-15

Source gene: PCDH15

Class: DEG_SCF_FBW7_1

Location: 159:164

E3 ligase: FBXW7

DEGRON score: 0.9694

ASA_SCORE: 55.8833

COIL: 0.9333

CONS_SCORE: 1

DSS_SCORE: 0.2747

HELIX: 0.01

FCONS_SCORE: 1.1362

RIG_SCORE: 0.7965

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P161T	TCGA-77-8009	LUSC	TCGA	LTPVGT	DEG_SCF_FBW7_1	0.7031
p.T155I	TCGA-94-A4VJ	LUSC	TCGA	LTPVGT	DEG_SCF_FBW7_1	0.2222
p.T165I	TCGA-A5-A0G1	UCEC	TCGA	LTPVGT	DEG_SCF_FBW7_1	0.3056
p.F170Y	TCGA-AG-A002	READ	TCGA	LTPVGT	DEG_SCF_FBW7_1	0.1667
p.V156M	TCGA-BK-A0C9	UCEC	TCGA	LTPVGT	DEG_SCF_FBW7_1	0.25
p.V156M	DO41253	UCEC	ICGC	LTPVGT	DEG_SCF_FBW7_1	0.25
p.G169E	TCGA-D3-A8GL	SKCM	TCGA	LTPVGT	DEG_SCF_FBW7_1	0.1944
p.G169E	TCGA-W3-AA1V	SKCM	TCGA	LTPVGT	DEG_SCF_FBW7_1	0.1944
p.G169R	TCGA-DA-A95Y	SKCM	TCGA	LTPVGT	DEG_SCF_FBW7_1	0.1944
p.Y152H	TCGA-DI-A1BU	UCEC	TCGA	LTPVGT	DEG_SCF_FBW7_1	0.1389
p.G163D	TCGA-EB-A3XF	SKCM	TCGA	LTPVGT	DEG_SCF_FBW7_1	0.6087
p.G163D	DO37437	SKCM	ICGC	LTPVGT	DEG_SCF_FBW7_1	0.6087
p.G163C	TCGA-LN-A49Y	ESCA	TCGA	LTPVGT	DEG_SCF_FBW7_1	0.6489
p.T173K	DO225012	BRCA	ICGC	LTPVGT	DEG_SCF_FBW7_1	0.0833
p.T160A	DO8264	COAD	ICGC	LTPVGT	DEG_SCF_FBW7_1	0.7139
p.V156A	DO230311	COCA	ICGC	LTPVGT	DEG_SCF_FBW7_1	0.25
p.I171T	DO233762	GACA	ICGC	LTPVGT	DEG_SCF_FBW7_1	0.1389
p.H154N	DO229029	LICA	ICGC	LTPVGT	DEG_SCF_FBW7_1	0.1944
p.T151S	DO25416	LUAD	ICGC	LTPVGT	DEG_SCF_FBW7_1	0.1111
p.G168C	DO224566	LUSC	ICGC	LTPVGT	DEG_SCF_FBW7_1	0.2222
p.G168C	DO231007	LUSC	ICGC	LTPVGT	DEG_SCF_FBW7_1	0.2222
p.G168V	DO224566	LUSC	ICGC	LTPVGT	DEG_SCF_FBW7_1	0.2222
p.G168V	DO231007	LUSC	ICGC	LTPVGT	DEG_SCF_FBW7_1	0.2222
p.T160I	DO50104	LUSC	ICGC	LTPVGT	DEG_SCF_FBW7_1	0.7078
p.P166T	DO27200	LUSC	ICGC	LTPVGT	DEG_SCF_FBW7_1	0.2778
p.G174E	DO222843	MELA	ICGC	LTPVGT	DEG_SCF_FBW7_1	0.0556
p.G174E	DO50287	SKCM	ICGC	LTPVGT	DEG_SCF_FBW7_1	0.0556
p.G174E	DO51276	SKCM	ICGC	LTPVGT	DEG_SCF_FBW7_1	0.0556
p.P150H	DO37643	SKCM	ICGC	LTPVGT	DEG_SCF_FBW7_1	0.0833
p.P150H	DO37405	SKCM	ICGC	LTPVGT	DEG_SCF_FBW7_1	0.0833
p.G174R	DO223908	SKCM	ICGC	LTPVGT	DEG_SCF_FBW7_1	0.0556
p.Y157H	DO42023	UCEC	ICGC	LTPVGT	DEG_SCF_FBW7_1	0.2778
p.T170I	DO42472	UCEC	ICGC	LTPVGT	DEG_SCF_FBW7_1	0.1667
p.N162S	SIDM00277	Acute Myeloid Leukemia	GDSC	LTPVGT	DEG_SCF_FBW7_1	0.7069
p.N162S	EoL-1-cell	haematopoietic_and_lymphoid_tissue	COSMIC	LTPVGT	DEG_SCF_FBW7_1	0.7069
p.N157S	ACH-000198	Leukemia	CCLE	LTPVGT	DEG_SCF_FBW7_1	0.2778
p.N157S	EoL-1-cell	haematopoietic_and_lymphoid_tissue	COSMIC	LTPVGT	DEG_SCF_FBW7_1	0.2778
p.F170C	ACH-000987	Skin Cancer	CCLE	LTPVGT	DEG_SCF_FBW7_1	0.1667
p.F170C	Mewo	skin	COSMIC	LTPVGT	DEG_SCF_FBW7_1	0.1667
p.T172K	HPAF-II	pancreas	COSMIC	LTPVGT	DEG_SCF_FBW7_1	0.1111
p.T172K	NCI-H1975	lung	COSMIC	LTPVGT	DEG_SCF_FBW7_1	0.1111
p.I165K	EN	endometrium	COSMIC	LTPVGT	DEG_SCF_FBW7_1	0.3056
p.Y167N	HCC-366	lung	COSMIC	LTPVGT	DEG_SCF_FBW7_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPVGT

Degron related mutations and impact score

Drug responses associated with PCDH15 mutations

All proteins holding degron of LTPVGT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96QU1	Protocadherin-15	DEG_SCF_FBW7_1	159:164	LTPVGT	FBXW7	0.9694	More...