DegronMD

Uniprot ID: Q96L50

Source protein: Leucine-rich repeat protein 1

Source gene: LRR1

Class: DEG_SCF_FBW7_1

Location: 123:128

E3 ligase: FBXW7

DEGRON score: 0.6648

ASA_SCORE: 75.3167

COIL: 0.7825

CONS_SCORE: 0.6696

DSS_SCORE: 0.302

HELIX: 0.1133

FCONS_SCORE: 0.9887

RIG_SCORE: 0.7972

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T128S	TCGA-AP-A1E0	UCEC	TCGA	LTPVKT	DEG_SCF_FBW7_1	0.7116
p.T128S	DO43154	UCEC	ICGC	LTPVKT	DEG_SCF_FBW7_1	0.7116
p.C114S	TCGA-DD-A4NK	LIHC	TCGA	LTPVKT	DEG_SCF_FBW7_1	0.0833
p.C114S	DO44882	LIHC	ICGC	LTPVKT	DEG_SCF_FBW7_1	0.0833
p.H127R	DO233784	GACA	ICGC	LTPVKT	DEG_SCF_FBW7_1	0.8244
p.C117F	DO48471	KIRP	ICGC	LTPVKT	DEG_SCF_FBW7_1	0.1667
p.C114F	DO228986	LICA	ICGC	LTPVKT	DEG_SCF_FBW7_1	0.0833
p.K120N	DO23580	LUAD	ICGC	LTPVKT	DEG_SCF_FBW7_1	0.25
p.H127Y	DO222843	MELA	ICGC	LTPVKT	DEG_SCF_FBW7_1	0.7229
p.C138R	DO219468	SKCM	ICGC	LTPVKT	DEG_SCF_FBW7_1	0.0556
p.V126A	SIDM02039	Colorectal Carcinoma	GDSC	LTPVKT	DEG_SCF_FBW7_1	0.5825
p.T136A	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	LTPVKT	DEG_SCF_FBW7_1	0.5556
p.T136A	SIDM01664	Prostate Carcinoma	GDSC	LTPVKT	DEG_SCF_FBW7_1	0.5556
p.P125S	SIDM00282	Colorectal Carcinoma	GDSC	LTPVKT	DEG_SCF_FBW7_1	0.6752
p.P125S	ACH-000998	Colon/Colorectal Cancer	CCLE	LTPVKT	DEG_SCF_FBW7_1	0.6752
p.P125S	CW-2	large_intestine	COSMIC	LTPVKT	DEG_SCF_FBW7_1	0.6752
p.K135E	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	LTPVKT	DEG_SCF_FBW7_1	0.5833
p.K135E	ACH-000637	Esophageal Cancer	CCLE	LTPVKT	DEG_SCF_FBW7_1	0.5833
p.K135E	KYSE-520	oesophagus	COSMIC	LTPVKT	DEG_SCF_FBW7_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96L50	Leucine-rich repeat protein 1	DEG_SCF_FBW7_1	123:128	LTPVKT	FBXW7	0.6648	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons