DegronMD - Q96L50(LRR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T128S	TCGA-AP-A1E0	UCEC	TCGA	LTPVKT	DEG_SCF_FBW7_1	123:128	Mutation altering degron motif	0.7116
p.T128S	DO43154	UCEC	ICGC	LTPVKT	DEG_SCF_FBW7_1	123:128	Mutation altering degron motif	0.7116
p.C114S	TCGA-DD-A4NK	LIHC	TCGA	LTPVKT	DEG_SCF_FBW7_1	123:128	Mutation rewiring degron network	0.0833
p.C114S	DO44882	LIHC	ICGC	LTPVKT	DEG_SCF_FBW7_1	123:128	Mutation rewiring degron network	0.0833
p.H127R	DO233784	GACA	ICGC	LTPVKT	DEG_SCF_FBW7_1	123:128	Mutation altering degron motif	0.8244
p.C117F	DO48471	KIRP	ICGC	LTPVKT	DEG_SCF_FBW7_1	123:128	Mutation rewiring degron network	0.1667
p.C114F	DO228986	LICA	ICGC	LTPVKT	DEG_SCF_FBW7_1	123:128	Mutation rewiring degron network	0.0833
p.V9L	DO229008	LICA	ICGC	MKLHCE	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.25
p.K120N	DO23580	LUAD	ICGC	LTPVKT	DEG_SCF_FBW7_1	123:128	Mutation rewiring degron network	0.25
p.H127Y	DO222843	MELA	ICGC	LTPVKT	DEG_SCF_FBW7_1	123:128	Mutation altering degron motif	0.7229
p.C138R	DO219468	SKCM	ICGC	LTPVKT	DEG_SCF_FBW7_1	123:128	Mutation rewiring degron network	0.0556
p.V126A	SIDM02039	Colorectal Carcinoma	GDSC	LTPVKT	DEG_SCF_FBW7_1	123:128	Mutation altering degron motif	0.5825
p.T136A	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	LTPVKT	DEG_SCF_FBW7_1	123:128	Mutation blocking phosphorylation signal	0.5556
p.T136A	SIDM01664	Prostate Carcinoma	GDSC	LTPVKT	DEG_SCF_FBW7_1	123:128	Mutation blocking phosphorylation signal	0.5556
p.P125S	SIDM00282	Colorectal Carcinoma	GDSC	LTPVKT	DEG_SCF_FBW7_1	123:128	Mutation altering degron motif	0.6752
p.P125S	ACH-000998	Colon/Colorectal Cancer	CCLE	LTPVKT	DEG_SCF_FBW7_1	123:128	Mutation altering degron motif	0.6752
p.P125S	CW-2	large intestine	COSMIC	LTPVKT	DEG_SCF_FBW7_1	123:128	Mutation altering degron motif	0.6752
p.K135E	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	LTPVKT	DEG_SCF_FBW7_1	123:128	Mutation blocking ubiquitination signal	0.5833
p.K135E	ACH-000637	Esophageal Cancer	CCLE	LTPVKT	DEG_SCF_FBW7_1	123:128	Mutation blocking ubiquitination signal	0.5833
p.K135E	KYSE-520	oesophagus	COSMIC	LTPVKT	DEG_SCF_FBW7_1	123:128	Mutation blocking ubiquitination signal	0.5833

Kaplan plot for LRR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRR1

UniProt ID: Q96L50

Entrez ID: 122769

Protein name: Leucine-rich repeat protein 1 (4-1BB-mediated-signaling molecule) (4-1BBlrr) (LRR-repeat protein 1) (LRR-1) (Peptidylprolyl isomerase-like 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRR1 in