DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
MKLHCE
Uniprot ID:
Q96L50
Source protein:
Leucine-rich repeat protein 1
Source gene:
LRR1
Class:
LIG_APCC_ABBA_1
Location:
1:6
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9281
ASA_SCORE:
70.6167
COIL:
0.4197
CONS_SCORE:
0.7202
DSS_SCORE:
0.6102
HELIX:
0.0015
FCONS_SCORE:
1.0547
RIG_SCORE:
0.8326
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V9L
DO229008
LICA
ICGC
MKLHCE
LIG_APCC_ABBA_1
0.25
Drug responses associated with LRR1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of MKLHCE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96L50
Leucine-rich repeat protein 1
LIG_APCC_ABBA_1
1:6
MKLHCE
APC,CDC20,FZR1
0.9281
More...