DegronMD

Uniprot ID: Q9BRB3

Source protein: Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q

Source gene: PIGQ

Class: DEG_SCF_FBW7_1

Location: 732:737

E3 ligase: FBXW7

DEGRON score: 0.9902

ASA_SCORE: 76.4

COIL: 0.861

CONS_SCORE: -1000

DSS_SCORE: 0.7347

HELIX: 0.0108

FCONS_SCORE: 1.2942

RIG_SCORE: 0.5666

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L743P	TCGA-AJ-A3EK	UCEC	TCGA	LTPVPS	DEG_SCF_FBW7_1	0.1667
p.L743P	DO41584	UCEC	ICGC	LTPVPS	DEG_SCF_FBW7_1	0.1667
p.P723H	TCGA-AX-A3FS	UCEC	TCGA	LTPVPS	DEG_SCF_FBW7_1	0.0833
p.P723H	DO40879	UCEC	ICGC	LTPVPS	DEG_SCF_FBW7_1	0.0833
p.K729T	TCGA-CC-A8HV	LIHC	TCGA	LTPVPS	DEG_SCF_FBW7_1	0.3611
p.K729T	DO52189	LIHC	ICGC	LTPVPS	DEG_SCF_FBW7_1	0.3611
p.V735I	TCGA-CK-6746	COAD	TCGA	LTPVPS	DEG_SCF_FBW7_1	0.5965
p.V735I	TCGA-IB-7651	PAAD	TCGA	LTPVPS	DEG_SCF_FBW7_1	0.5965
p.V735I	DO7938	COAD	ICGC	LTPVPS	DEG_SCF_FBW7_1	0.5965
p.V735I	DO46657	PAAD	ICGC	LTPVPS	DEG_SCF_FBW7_1	0.5965
p.P734T	TCGA-FS-A1Z0	SKCM	TCGA	LTPVPS	DEG_SCF_FBW7_1	0.7031
p.P734T	DO37431	SKCM	ICGC	LTPVPS	DEG_SCF_FBW7_1	0.7031
p.P739L	TCGA-Z2-AA3S	SKCM	TCGA	LTPVPS	DEG_SCF_FBW7_1	0.2778
p.P739L	DO51302	SKCM	ICGC	LTPVPS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BRB3	Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q	DEG_SCF_FBW7_1	732:737	LTPVPS	FBXW7	0.9902	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons