DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_1

Location: 9266:9273

E3 ligase: FBXW7

DEGRON score: 0.9495

ASA_SCORE: 87.3875

COIL: 0.8694

CONS_SCORE: 0

DSS_SCORE: 0.468

HELIX: 0.0203

FCONS_SCORE: 0

RIG_SCORE: 0.7627

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D9262Y	TCGA-B5-A1MR	UCEC	TCGA	LTSTPAFS	DEG_SCF_FBW7_1	0.2222
p.D9262Y	DO41758	UCEC	ICGC	LTSTPAFS	DEG_SCF_FBW7_1	0.2222
p.T9263R	TCGA-CR-7402	HNSC	TCGA	LTSTPAFS	DEG_SCF_FBW7_1	0.25
p.T9263R	DO15727	HNSC	ICGC	LTSTPAFS	DEG_SCF_FBW7_1	0.25
p.T9263I	TCGA-E6-A1LX	UCEC	TCGA	LTSTPAFS	DEG_SCF_FBW7_1	0.25
p.T9263I	DO41020	UCEC	ICGC	LTSTPAFS	DEG_SCF_FBW7_1	0.25
p.L9266I	DO222762	COCA	ICGC	LTSTPAFS	DEG_SCF_FBW7_1	0.6063
p.S9276I	DO44868	LICA	ICGC	LTSTPAFS	DEG_SCF_FBW7_1	0.25
p.D9262G	DO23188	LINC	ICGC	LTSTPAFS	DEG_SCF_FBW7_1	0.2222
p.R9277K	DO220889	MELA	ICGC	LTSTPAFS	DEG_SCF_FBW7_1	0.2222
p.R9277M	DO220907	MELA	ICGC	LTSTPAFS	DEG_SCF_FBW7_1	0.2222
p.P9270S	DO222702	MELA	ICGC	LTSTPAFS	DEG_SCF_FBW7_1	0.6752
p.S9273F	DO222880	MELA	ICGC	LTSTPAFS	DEG_SCF_FBW7_1	0.7982
p.K9283R	SIDM00704	Small Cell Lung Carcinoma	GDSC	LTSTPAFS	DEG_SCF_FBW7_1	0.1667
p.K9283R	ACH-000639	Lung Cancer	CCLE	LTSTPAFS	DEG_SCF_FBW7_1	0.1667
p.K9283R	NCI-H211	lung	COSMIC	LTSTPAFS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	9266:9273	LTSTPAFS	FBXW7	0.9495	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons