DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 336:343

E3 ligase: FBXW7

DEGRON score: 0.982

ASA_SCORE: 83.4875

COIL: 0.7703

CONS_SCORE: 0.7147

DSS_SCORE: 0.6177

HELIX: 0.0161

FCONS_SCORE: 1.1626

RIG_SCORE: 0.6808

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V346F	TCGA-50-5931	LUAD	TCGA	LTSTPAST	DEG_SCF_FBW7_1	0.25
p.V346F	DO24980	LUAD	ICGC	LTSTPAST	DEG_SCF_FBW7_1	0.25
p.A347V	TCGA-BK-A6W3	UCEC	TCGA	LTSTPAST	DEG_SCF_FBW7_1	0.2222
p.A347V	DO50076	UCEC	ICGC	LTSTPAST	DEG_SCF_FBW7_1	0.2222
p.T339M	DO882	BOCA	ICGC	LTSTPAST	DEG_SCF_FBW7_1	0.7423
p.T339M	DO229016	COCA	ICGC	LTSTPAST	DEG_SCF_FBW7_1	0.7423
p.T339M	DO230659	LAML	ICGC	LTSTPAST	DEG_SCF_FBW7_1	0.7423
p.T339M	DO231140	LAML	ICGC	LTSTPAST	DEG_SCF_FBW7_1	0.7423
p.T339M	DO228941	LICA	ICGC	LTSTPAST	DEG_SCF_FBW7_1	0.7423
p.T339M	DO228947	LICA	ICGC	LTSTPAST	DEG_SCF_FBW7_1	0.7423
p.P345L	DO10858	ESAD	ICGC	LTSTPAST	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_1	336:343	LTSTPAST	FBXW7	0.982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons