DegronMD

Uniprot ID: P10244

Source protein: Myb-related protein B

Source gene: MYBL2

Class: DEG_SCF_FBW7_1

Location: 473:480

E3 ligase: FBXW7

DEGRON score: 0.9984

ASA_SCORE: 70.6625

COIL: 0.8443

CONS_SCORE: 0.3432

DSS_SCORE: 0.3517

HELIX: 0.0551

FCONS_SCORE: 0.9664

RIG_SCORE: 0.7271

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L473Q	TCGA-AC-A5XU	BRCA	TCGA	LTSTPVCS	DEG_SCF_FBW7_1	0.7765
p.E469D	TCGA-AP-A1DV	UCEC	TCGA	LTSTPVCS	DEG_SCF_FBW7_1	0.2222
p.T474K	TCGA-CK-4951	COAD	TCGA	LTSTPVCS	DEG_SCF_FBW7_1	0.6195
p.V478A	TCGA-N7-A4Y0	UCS	TCGA	LTSTPVCS	DEG_SCF_FBW7_1	0.5825
p.D468N	DO233251	GACA	ICGC	LTSTPVCS	DEG_SCF_FBW7_1	0.1944
p.Q484L	DO228203	LICA	ICGC	LTSTPVCS	DEG_SCF_FBW7_1	0.2222
p.M488I	DO23818	LUAD	ICGC	LTSTPVCS	DEG_SCF_FBW7_1	0.1111
p.P471S	DO23687	LUAD	ICGC	LTSTPVCS	DEG_SCF_FBW7_1	0.2778
p.A478V	DO41020	UCEC	ICGC	LTSTPVCS	DEG_SCF_FBW7_1	0.6936
p.A478V	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	LTSTPVCS	DEG_SCF_FBW7_1	0.6936
p.D483N	DO41584	UCEC	ICGC	LTSTPVCS	DEG_SCF_FBW7_1	0.25
p.T465I	NCI-H630	large_intestine	COSMIC	LTSTPVCS	DEG_SCF_FBW7_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10244	Myb-related protein B	DEG_SCF_FBW7_1	473:480	LTSTPVCS	FBXW7	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons