DegronMD

Uniprot ID: P57737

Source protein: Coronin-7

Source gene: CORO7

Class: DEG_SCF_FBW7_1

Location: 495:501

E3 ligase: FBXW7

DEGRON score: 0.7075

ASA_SCORE: 38.9857

COIL: 0.7131

CONS_SCORE: 0.3969

DSS_SCORE: 0.3081

HELIX: 0.0794

FCONS_SCORE: 1.0077

RIG_SCORE: 0.7239

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L493R	TCGA-BH-A0EE	BRCA	TCGA	LTTPGES	DEG_SCF_FBW7_1	0.2778
p.G503S	TCGA-CA-6717	COAD	TCGA	LTTPGES	DEG_SCF_FBW7_1	0.2778
p.G499C	TCGA-EE-A181	SKCM	TCGA	LTTPGES	DEG_SCF_FBW7_1	0.6489
p.E492D	DO48409	BLCA	ICGC	LTTPGES	DEG_SCF_FBW7_1	0.25
p.E492D	DO229005	COCA	ICGC	LTTPGES	DEG_SCF_FBW7_1	0.25
p.V504L	DO51920	BLCA	ICGC	LTTPGES	DEG_SCF_FBW7_1	0.25
p.A498V	DO8722	COAD	ICGC	LTTPGES	DEG_SCF_FBW7_1	0.6936
p.T509M	DO38839	STAD	ICGC	LTTPGES	DEG_SCF_FBW7_1	0.1111
p.A506V	ACH-000999	Colon/Colorectal Cancer	CCLE	LTTPGES	DEG_SCF_FBW7_1	0.1944
p.A506V	SNU-1040	large_intestine	COSMIC	LTTPGES	DEG_SCF_FBW7_1	0.1944
p.V495M	A375	skin	COSMIC	LTTPGES	DEG_SCF_FBW7_1	0.7208
p.K511N	MDA-MB-175-VII	breast	COSMIC	LTTPGES	DEG_SCF_FBW7_1	0.0556
p.A488V	SNU-1040	large_intestine	COSMIC	LTTPGES	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P57737	Coronin-7	DEG_SCF_FBW7_1	495:501	LTTPGES	FBXW7	0.7075	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons