DegronMD

Uniprot ID: P13984

Source protein: General transcription factor IIF subunit 2

Source gene: GTF2F2

Class: LIG_APCC_ABBA_1

Location: 93:98

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8052

ASA_SCORE: 46.8333

COIL: 0.3855

CONS_SCORE: 0.5481

DSS_SCORE: 0.3517

HELIX: 0.1045

FCONS_SCORE: 1.2129

RIG_SCORE: 0.81

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G90E	TCGA-22-5481	LUSC	TCGA	LTVFTE	LIG_APCC_ABBA_1	0.25
p.G90E	DO27160	LUSC	ICGC	LTVFTE	LIG_APCC_ABBA_1	0.25
p.S99I	TCGA-AX-A06F	UCEC	TCGA	LTVFTE	LIG_APCC_ABBA_1	0.3056
p.S99I	DO41752	UCEC	ICGC	LTVFTE	LIG_APCC_ABBA_1	0.3056
p.L104P	TCGA-EY-A5W2	UCEC	TCGA	LTVFTE	LIG_APCC_ABBA_1	0.1667
p.L104P	DO48177	UCEC	ICGC	LTVFTE	LIG_APCC_ABBA_1	0.1667
p.E98K	DO223057	ESCA	ICGC	LTVFTE	LIG_APCC_ABBA_1	0.7022
p.T92S	DO233169	GACA	ICGC	LTVFTE	LIG_APCC_ABBA_1	0.3056
p.V84F	DO229018	LICA	ICGC	LTVFTE	LIG_APCC_ABBA_1	0.0833
p.S87I	DO229035	LICA	ICGC	LTVFTE	LIG_APCC_ABBA_1	0.6111
p.E98D	DO229068	PRAD	ICGC	LTVFTE	LIG_APCC_ABBA_1	0.5647
p.K103N	DO229268	THCA	ICGC	LTVFTE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13984	General transcription factor IIF subunit 2	LIG_APCC_ABBA_1	93:98	LTVFTE	APC,CDC20,FZR1	0.8052	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons