DegronMD

Uniprot ID: Q6PEZ8

Source protein: Podocan-like protein 1

Source gene: PODNL1

Class: DEG_SCF_FBW7_1

Location: 378:385

E3 ligase: FBXW7

DEGRON score: 0.7076

ASA_SCORE: 36

COIL: 0.9273

CONS_SCORE: 0.4354

DSS_SCORE: 0.1077

HELIX: 0.0566

FCONS_SCORE: 0.7884

RIG_SCORE: 0.7992

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A395T	DO229213	THCA	ICGC	LVATPGLT	DEG_SCF_FBW7_1	0.0556
p.V370M	ACH-000132	Ovarian Cancer	CCLE	LVATPGLT	DEG_SCF_FBW7_1	0.1111
p.R376G	ACH-001628	Ovarian Cancer	CCLE	LVATPGLT	DEG_SCF_FBW7_1	0.2778
p.D387N	Sarc9371	bone	COSMIC	LVATPGLT	DEG_SCF_FBW7_1	0.2778
p.D378N	Sarc9371	bone	COSMIC	LVATPGLT	DEG_SCF_FBW7_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PEZ8	Podocan-like protein 1	DEG_SCF_FBW7_1	378:385	LVATPGLT	FBXW7	0.7076	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons