DegronMD - Q6PEZ8(PODNL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G451S	DO222765	COCA	ICGC	QRNQLRMLE	DEG_APCC_DBOX_1	437:445	Mutation rewiring degron network	0.1667
p.R442Q	DO234353	ESAD	ICGC	QRNQLRMLE	DEG_APCC_DBOX_1	437:445	Mutation altering degron motif	0.6218
p.A395T	DO229213	THCA	ICGC	LVATPGLT	DEG_SCF_FBW7_1	378:385	Mutation rewiring degron network	0.0556
p.R436C	SIDM00650	Small Cell Lung Carcinoma	GDSC	QRNQLRMLE	DEG_APCC_DBOX_1	437:445	Mutation rewiring degron network	0.3056
p.R436C	SIDM00879	Breast Carcinoma	GDSC	QRNQLRMLE	DEG_APCC_DBOX_1	437:445	Mutation rewiring degron network	0.3056
p.R436C	SIDM01681	Non-Cancerous	GDSC	QRNQLRMLE	DEG_APCC_DBOX_1	437:445	Mutation rewiring degron network	0.3056
p.G449S	SIDM01347	Ovarian Carcinoma	GDSC	QRNQLRMLE	DEG_APCC_DBOX_1	437:445	Mutation rewiring degron network	0.2222
p.V370M	ACH-000132	Ovarian Cancer	CCLE	LVATPGLT	DEG_SCF_FBW7_1	378:385	Mutation rewiring degron network	0.1111
p.R432H	ACH-000932	Gastric Cancer	CCLE	QRNQLRMLE	DEG_APCC_DBOX_1	437:445	Mutation rewiring degron network	0.1944
p.R376G	ACH-001628	Ovarian Cancer	CCLE	LVATPGLT	DEG_SCF_FBW7_1	378:385	Mutation rewiring degron network	0.2778
p.D387N	Sarc9371	bone	COSMIC	LVATPGLT	DEG_SCF_FBW7_1	378:385	Mutation rewiring degron network	0.2778
p.D378N	Sarc9371	bone	COSMIC	LVATPGLT	DEG_SCF_FBW7_1	378:385	Mutation altering degron motif	0.6932

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons