DegronMD

Uniprot ID: Q6PEZ8

Source protein: Podocan-like protein 1

Source gene: PODNL1

Class: DEG_APCC_DBOX_1

Location: 437:445

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9684

ASA_SCORE: 70.1444

COIL: 0.7052

CONS_SCORE: 0.4439

DSS_SCORE: 0.3664

HELIX: 0.0207

FCONS_SCORE: 0.9527

RIG_SCORE: 0.7842

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G451S	DO222765	COCA	ICGC	QRNQLRMLE	DEG_APCC_DBOX_1	0.1667
p.R442Q	DO234353	ESAD	ICGC	QRNQLRMLE	DEG_APCC_DBOX_1	0.6218
p.R436C	SIDM00650	Small Cell Lung Carcinoma	GDSC	QRNQLRMLE	DEG_APCC_DBOX_1	0.3056
p.R436C	SIDM00879	Breast Carcinoma	GDSC	QRNQLRMLE	DEG_APCC_DBOX_1	0.3056
p.R436C	SIDM01681	Non-Cancerous	GDSC	QRNQLRMLE	DEG_APCC_DBOX_1	0.3056
p.G449S	SIDM01347	Ovarian Carcinoma	GDSC	QRNQLRMLE	DEG_APCC_DBOX_1	0.2222
p.R432H	ACH-000932	Gastric Cancer	CCLE	QRNQLRMLE	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PEZ8	Podocan-like protein 1	DEG_APCC_DBOX_1	437:445	QRNQLRMLE	APC,CDC20,FZR1	0.9684	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons