DegronMD

Uniprot ID: Q93062

Source protein: RNA-binding protein with multiple splicing

Source gene: RBPMS

Class: DEG_SCF_FBW7_1

Location: 110:117

E3 ligase: FBXW7

DEGRON score: 0.9671

ASA_SCORE: 77.7875

COIL: 0.9231

CONS_SCORE: 0.5164

DSS_SCORE: 0.5671

HELIX: 0.0223

FCONS_SCORE: 0.9141

RIG_SCORE: 0.6395

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F127L	TCGA-AA-3510	COAD	TCGA	LVGTPNPS	DEG_SCF_FBW7_1	0.0556
p.T103M	TCGA-VQ-A8P2	STAD	TCGA	LVGTPNPS	DEG_SCF_FBW7_1	0.1389
p.T103M	DO51761	STAD	ICGC	LVGTPNPS	DEG_SCF_FBW7_1	0.1389
p.A107G	DO233517	PRAD	ICGC	LVGTPNPS	DEG_SCF_FBW7_1	0.3611
p.K107N	SIDM01611	Endometrial Carcinoma	GDSC	LVGTPNPS	DEG_SCF_FBW7_1	0.3611
p.K107N	ACH-000996	Endometrial/Uterine Cancer	CCLE	LVGTPNPS	DEG_SCF_FBW7_1	0.3611
p.V124A	ACH-001991	Primary	CCLE	LVGTPNPS	DEG_SCF_FBW7_1	0.1389
p.S120R	MCC13	skin	COSMIC	LVGTPNPS	DEG_SCF_FBW7_1	0.25
p.P114L	LN-18	central_nervous_system	COSMIC	LVGTPNPS	DEG_SCF_FBW7_1	0.7582
p.M114L	LP-1	haematopoietic_and_lymphoid_tissue	COSMIC	LVGTPNPS	DEG_SCF_FBW7_1	0.711
p.T109P	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	LVGTPNPS	DEG_SCF_FBW7_1	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q93062	RNA-binding protein with multiple splicing	DEG_SCF_FBW7_1	110:117	LVGTPNPS	FBXW7	0.9671	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons