DegronMD

Uniprot ID: Q9Y334

Source protein: von Willebrand factor A domain-containing protein 7

Source gene: VWA7

Class: LIG_APCC_ABBA_1

Location: 356:361

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8364

ASA_SCORE: 31.8

COIL: 0.388

CONS_SCORE: 0.8931

DSS_SCORE: 0.2837

HELIX: 0.0222

FCONS_SCORE: 1.3356

RIG_SCORE: 0.7732

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P351H	TCGA-AX-A1CE	UCEC	TCGA	LVPFHD	LIG_APCC_ABBA_1	0.1944
p.P351H	DO42280	UCEC	ICGC	LVPFHD	LIG_APCC_ABBA_1	0.1944
p.P348S	TCGA-EE-A2MR	SKCM	TCGA	LVPFHD	LIG_APCC_ABBA_1	0.1111
p.P348S	DO37819	SKCM	ICGC	LVPFHD	LIG_APCC_ABBA_1	0.1111
p.P351T	DO233103	GACA	ICGC	LVPFHD	LIG_APCC_ABBA_1	0.1944
p.S347N	DO233634	GACA	ICGC	LVPFHD	LIG_APCC_ABBA_1	0.0833
p.S347N	SIDM01619	Endometrial Carcinoma	GDSC	LVPFHD	LIG_APCC_ABBA_1	0.0833
p.S347N	ACH-000984	Endometrial/Uterine Cancer	CCLE	LVPFHD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y334	von Willebrand factor A domain-containing protein 7	LIG_APCC_ABBA_1	356:361	LVPFHD	APC,CDC20,FZR1	0.8364	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons