DegronMD

Uniprot ID: P49792

Source protein: E3 SUMO-protein ligase RanBP2

Source gene: RANBP2

Class: DEG_SCF_FBW7_2

Location: 1410:1416

E3 ligase: FBXW7

DEGRON score: 0.7753

ASA_SCORE: 85.1429

COIL: 0.749

CONS_SCORE: 0.2806

DSS_SCORE: 0.2438

HELIX: 0.0787

FCONS_SCORE: 0.9409

RIG_SCORE: 0.7873

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1404F	TCGA-49-4487	LUAD	TCGA	LVTPKKE	DEG_SCF_FBW7_2	0.1667
p.V1404F	DO24780	LUAD	ICGC	LVTPKKE	DEG_SCF_FBW7_2	0.1667
p.R1407Q	TCGA-AP-A056	UCEC	TCGA	LVTPKKE	DEG_SCF_FBW7_2	0.25
p.R1407Q	DO43971	UCEC	ICGC	LVTPKKE	DEG_SCF_FBW7_2	0.25
p.S1422N	TCGA-AP-A0LM	UCEC	TCGA	LVTPKKE	DEG_SCF_FBW7_2	0.6111
p.S1422N	DO43306	UCEC	ICGC	LVTPKKE	DEG_SCF_FBW7_2	0.6111
p.S1422N	ACH-000123	Ovarian Cancer	CCLE	LVTPKKE	DEG_SCF_FBW7_2	0.6111
p.A1409T	TCGA-EY-A215	UCEC	TCGA	LVTPKKE	DEG_SCF_FBW7_2	0.3056
p.A1409T	DO42665	UCEC	ICGC	LVTPKKE	DEG_SCF_FBW7_2	0.3056
p.E1416K	TCGA-ND-A4WC	UCS	TCGA	LVTPKKE	DEG_SCF_FBW7_2	0.7022
p.S1422G	DO8858	COAD	ICGC	LVTPKKE	DEG_SCF_FBW7_2	0.6111
p.W1419L	SIDM00330	Neuroblastoma	GDSC	LVTPKKE	DEG_SCF_FBW7_2	0.25
p.W1419L	ACH-001355	Neuroblastoma	CCLE	LVTPKKE	DEG_SCF_FBW7_2	0.25
p.W1419L	LAN-6	autonomic_ganglia	COSMIC	LVTPKKE	DEG_SCF_FBW7_2	0.25
p.V1404I	SIDM00156	Neuroblastoma	GDSC	LVTPKKE	DEG_SCF_FBW7_2	0.1667
p.V1404I	NB7	autonomic_ganglia	COSMIC	LVTPKKE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49792	E3 SUMO-protein ligase RanBP2	DEG_SCF_FBW7_2	1410:1416	LVTPKKE	FBXW7	0.7753	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons