DegronMD

Uniprot ID: Q9HCI6

Source protein: E3 SUMO-protein ligase KIAA1586

Source gene: KIAA1586

Class: DEG_SCF_FBW7_1

Location: 188:194

E3 ligase: FBXW7

DEGRON score: 0.9428

ASA_SCORE: 59.9

COIL: 0.672

CONS_SCORE: 1

DSS_SCORE: 0.3855

HELIX: 0.0466

FCONS_SCORE: 1

RIG_SCORE: 0.7509

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S202Y	TCGA-06-5416	GBM	TCGA	LVTPNGS	DEG_SCF_FBW7_1	0.1111
p.S202Y	DO10880	GBM	ICGC	LVTPNGS	DEG_SCF_FBW7_1	0.1111
p.P191S	TCGA-18-3409	LUSC	TCGA	LVTPNGS	DEG_SCF_FBW7_1	0.6752
p.P191S	DO26444	LUSC	ICGC	LVTPNGS	DEG_SCF_FBW7_1	0.6752
p.P191L	TCGA-18-3409	LUSC	TCGA	LVTPNGS	DEG_SCF_FBW7_1	0.7582
p.P191L	DO26444	LUSC	ICGC	LVTPNGS	DEG_SCF_FBW7_1	0.7582
p.G193D	TCGA-AJ-A3EL	UCEC	TCGA	LVTPNGS	DEG_SCF_FBW7_1	0.6087
p.G193D	DO41542	UCEC	ICGC	LVTPNGS	DEG_SCF_FBW7_1	0.6087
p.P191H	TCGA-AJ-A3IA	UCEC	TCGA	LVTPNGS	DEG_SCF_FBW7_1	0.7694
p.P191H	DO43082	UCEC	ICGC	LVTPNGS	DEG_SCF_FBW7_1	0.7694
p.R204Q	TCGA-AX-A2HC	UCEC	TCGA	LVTPNGS	DEG_SCF_FBW7_1	0.0556
p.R204Q	DO41572	UCEC	ICGC	LVTPNGS	DEG_SCF_FBW7_1	0.0556
p.L188S	TCGA-CG-4437	STAD	TCGA	LVTPNGS	DEG_SCF_FBW7_1	0.7667
p.L188S	DO38467	STAD	ICGC	LVTPNGS	DEG_SCF_FBW7_1	0.7667
p.S181F	TCGA-GF-A3OT	SKCM	TCGA	LVTPNGS	DEG_SCF_FBW7_1	0.1389
p.S181F	DO47288	SKCM	ICGC	LVTPNGS	DEG_SCF_FBW7_1	0.1389
p.P191A	DO223433	CLLE	ICGC	LVTPNGS	DEG_SCF_FBW7_1	0.7503
p.V178A	DO227657	COCA	ICGC	LVTPNGS	DEG_SCF_FBW7_1	0.0556
p.R204P	SIDM00967	Ovarian Carcinoma	GDSC	LVTPNGS	DEG_SCF_FBW7_1	0.0556
p.R204P	ACH-002181	Ovarian Cancer	CCLE	LVTPNGS	DEG_SCF_FBW7_1	0.0556
p.R204P	OVCA420	ovary	COSMIC	LVTPNGS	DEG_SCF_FBW7_1	0.0556
p.L203I	SIDM00498	Colorectal Carcinoma	GDSC	LVTPNGS	DEG_SCF_FBW7_1	0.0833
p.L203I	ACH-000970	Colon/Colorectal Cancer	CCLE	LVTPNGS	DEG_SCF_FBW7_1	0.0833
p.L203I	SNU-C5	large_intestine	COSMIC	LVTPNGS	DEG_SCF_FBW7_1	0.0833
p.H179P	ACH-001796	Liposarcoma	CCLE	LVTPNGS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCI6	E3 SUMO-protein ligase KIAA1586	DEG_SCF_FBW7_1	188:194	LVTPNGS	FBXW7	0.9428	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons