DegronMD - Q9HCI6(KIAA1586)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S202Y	TCGA-06-5416	GBM	TCGA	LVTPNGS	DEG_SCF_FBW7_1	188:194	Mutation rewiring degron network	0.1111
p.S202Y	DO10880	GBM	ICGC	LVTPNGS	DEG_SCF_FBW7_1	188:194	Mutation rewiring degron network	0.1111
p.P191S	TCGA-18-3409	LUSC	TCGA	LVTPNGS	DEG_SCF_FBW7_1	188:194	Mutation altering degron motif	0.6752
p.P191S	DO26444	LUSC	ICGC	LVTPNGS	DEG_SCF_FBW7_1	188:194	Mutation altering degron motif	0.6752
p.P191L	TCGA-18-3409	LUSC	TCGA	LVTPNGS	DEG_SCF_FBW7_1	188:194	Mutation altering degron motif	0.7582
p.P191L	DO26444	LUSC	ICGC	LVTPNGS	DEG_SCF_FBW7_1	188:194	Mutation altering degron motif	0.7582
p.L43H	TCGA-AA-3815	COAD	TCGA	SRPVLEYID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.7313
p.L43H	DO9924	COAD	ICGC	SRPVLEYID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.7313
p.D47N	TCGA-AA-3977	COAD	TCGA	SRPVLEYID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.5821
p.D47N	TCGA-AZ-4315	COAD	TCGA	SRPVLEYID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.5821
p.D47N	TCGA-B5-A1MR	UCEC	TCGA	SRPVLEYID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.5821
p.D47N	TCGA-EO-A3B0	UCEC	TCGA	SRPVLEYID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.5821
p.D47N	DO8842	COAD	ICGC	SRPVLEYID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.5821
p.D47N	DO8730	COAD	ICGC	SRPVLEYID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.5821
p.D47N	DO233903	GACA	ICGC	SRPVLEYID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.5821
p.D47N	DO219773	UCEC	ICGC	SRPVLEYID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.5821
p.D47N	DO41758	UCEC	ICGC	SRPVLEYID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.5821
p.G193D	TCGA-AJ-A3EL	UCEC	TCGA	LVTPNGS	DEG_SCF_FBW7_1	188:194	Mutation altering degron motif	0.6087
p.G193D	DO41542	UCEC	ICGC	LVTPNGS	DEG_SCF_FBW7_1	188:194	Mutation altering degron motif	0.6087
p.P191H	TCGA-AJ-A3IA	UCEC	TCGA	LVTPNGS	DEG_SCF_FBW7_1	188:194	Mutation altering degron motif	0.7694
p.P191H	DO43082	UCEC	ICGC	LVTPNGS	DEG_SCF_FBW7_1	188:194	Mutation altering degron motif	0.7694
p.R204Q	TCGA-AX-A2HC	UCEC	TCGA	LVTPNGS	DEG_SCF_FBW7_1	188:194	Mutation rewiring degron network	0.0556
p.R204Q	DO41572	UCEC	ICGC	LVTPNGS	DEG_SCF_FBW7_1	188:194	Mutation rewiring degron network	0.0556
p.C50Y	TCGA-B5-A1MX	UCEC	TCGA	SRPVLEYID	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25
p.C50Y	DO41999	UCEC	ICGC	SRPVLEYID	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25
p.L188S	TCGA-CG-4437	STAD	TCGA	LVTPNGS	DEG_SCF_FBW7_1	188:194	Mutation altering degron motif	0.7667
p.L188S	DO38467	STAD	ICGC	LVTPNGS	DEG_SCF_FBW7_1	188:194	Mutation altering degron motif	0.7667
p.L43V	TCGA-DK-AA71	BLCA	TCGA	SRPVLEYID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.6765
p.L43V	DO219010	BLCA	ICGC	SRPVLEYID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.6765
p.S181F	TCGA-GF-A3OT	SKCM	TCGA	LVTPNGS	DEG_SCF_FBW7_1	188:194	Mutation rewiring degron network	0.1389
p.S181F	DO47288	SKCM	ICGC	LVTPNGS	DEG_SCF_FBW7_1	188:194	Mutation rewiring degron network	0.1389
p.P191A	DO223433	CLLE	ICGC	LVTPNGS	DEG_SCF_FBW7_1	188:194	Mutation altering degron motif	0.7503
p.V178A	DO227657	COCA	ICGC	LVTPNGS	DEG_SCF_FBW7_1	188:194	Mutation rewiring degron network	0.0556
p.V42F	DO229034	LICA	ICGC	SRPVLEYID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.5957
p.R204P	SIDM00967	Ovarian Carcinoma	GDSC	LVTPNGS	DEG_SCF_FBW7_1	188:194	Mutation rewiring degron network	0.0556
p.R204P	ACH-002181	Ovarian Cancer	CCLE	LVTPNGS	DEG_SCF_FBW7_1	188:194	Mutation rewiring degron network	0.0556
p.R204P	OVCA420	ovary	COSMIC	LVTPNGS	DEG_SCF_FBW7_1	188:194	Mutation rewiring degron network	0.0556
p.L203I	SIDM00498	Colorectal Carcinoma	GDSC	LVTPNGS	DEG_SCF_FBW7_1	188:194	Mutation rewiring degron network	0.0833
p.L203I	ACH-000970	Colon/Colorectal Cancer	CCLE	LVTPNGS	DEG_SCF_FBW7_1	188:194	Mutation rewiring degron network	0.0833
p.L203I	SNU-C5	large intestine	COSMIC	LVTPNGS	DEG_SCF_FBW7_1	188:194	Mutation rewiring degron network	0.0833
p.H179P	ACH-001796	Liposarcoma	CCLE	LVTPNGS	DEG_SCF_FBW7_1	188:194	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIAA1586

UniProt ID: Q9HCI6

Entrez ID: 57691

Protein name: E3 SUMO-protein ligase KIAA1586 (EC 2.3.2.-) (E3 SUMO-protein transferase KIAA1586)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIAA1586 in