DegronMD

Uniprot ID: Q9HCI6

Source protein: E3 SUMO-protein ligase KIAA1586

Source gene: KIAA1586

Class: DEG_APCC_DBOX_1

Location: 39:47

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5373

ASA_SCORE: 75.2889

COIL: 0.47

CONS_SCORE: 1

DSS_SCORE: 0.4427

HELIX: 0.3153

FCONS_SCORE: 1.1

RIG_SCORE: 0.8073

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L43H	TCGA-AA-3815	COAD	TCGA	SRPVLEYID	DEG_APCC_DBOX_1	0.7313
p.L43H	DO9924	COAD	ICGC	SRPVLEYID	DEG_APCC_DBOX_1	0.7313
p.D47N	TCGA-AA-3977	COAD	TCGA	SRPVLEYID	DEG_APCC_DBOX_1	0.5821
p.D47N	TCGA-AZ-4315	COAD	TCGA	SRPVLEYID	DEG_APCC_DBOX_1	0.5821
p.D47N	TCGA-B5-A1MR	UCEC	TCGA	SRPVLEYID	DEG_APCC_DBOX_1	0.5821
p.D47N	TCGA-EO-A3B0	UCEC	TCGA	SRPVLEYID	DEG_APCC_DBOX_1	0.5821
p.D47N	DO8842	COAD	ICGC	SRPVLEYID	DEG_APCC_DBOX_1	0.5821
p.D47N	DO8730	COAD	ICGC	SRPVLEYID	DEG_APCC_DBOX_1	0.5821
p.D47N	DO233903	GACA	ICGC	SRPVLEYID	DEG_APCC_DBOX_1	0.5821
p.D47N	DO219773	UCEC	ICGC	SRPVLEYID	DEG_APCC_DBOX_1	0.5821
p.D47N	DO41758	UCEC	ICGC	SRPVLEYID	DEG_APCC_DBOX_1	0.5821
p.C50Y	TCGA-B5-A1MX	UCEC	TCGA	SRPVLEYID	DEG_APCC_DBOX_1	0.25
p.C50Y	DO41999	UCEC	ICGC	SRPVLEYID	DEG_APCC_DBOX_1	0.25
p.L43V	TCGA-DK-AA71	BLCA	TCGA	SRPVLEYID	DEG_APCC_DBOX_1	0.6765
p.L43V	DO219010	BLCA	ICGC	SRPVLEYID	DEG_APCC_DBOX_1	0.6765
p.V42F	DO229034	LICA	ICGC	SRPVLEYID	DEG_APCC_DBOX_1	0.5957

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCI6	E3 SUMO-protein ligase KIAA1586	DEG_APCC_DBOX_1	39:47	SRPVLEYID	APC,CDC20,FZR1	0.5373	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons