DegronMD

Uniprot ID: Q5VUA4

Source protein: Zinc finger protein 318

Source gene: ZNF318

Class: DEG_SCF_FBW7_1

Location: 1290:1296

E3 ligase: FBXW7

DEGRON score: 0.9968

ASA_SCORE: 81.7286

COIL: 0.9189

CONS_SCORE: 0.2496

DSS_SCORE: 0.5193

HELIX: 0.0504

FCONS_SCORE: 0.8722

RIG_SCORE: 0.703

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1302Q	TCGA-C5-A2LY	CESC	TCGA	LVTPSIS	DEG_SCF_FBW7_1	0.1667
p.E1302Q	DO6314	CESC	ICGC	LVTPSIS	DEG_SCF_FBW7_1	0.1667
p.K1280N	TCGA-EO-A22R	UCEC	TCGA	LVTPSIS	DEG_SCF_FBW7_1	0.1667
p.K1280N	DO42713	UCEC	ICGC	LVTPSIS	DEG_SCF_FBW7_1	0.1667
p.E1299D	TCGA-F5-6814	READ	TCGA	LVTPSIS	DEG_SCF_FBW7_1	0.25
p.E1299D	DO36556	READ	ICGC	LVTPSIS	DEG_SCF_FBW7_1	0.25
p.S1296C	TCGA-G2-AA3C	BLCA	TCGA	LVTPSIS	DEG_SCF_FBW7_1	0.8652
p.S1296C	DO51883	BLCA	ICGC	LVTPSIS	DEG_SCF_FBW7_1	0.8652
p.T1292I	DO227999	COCA	ICGC	LVTPSIS	DEG_SCF_FBW7_1	0.7078
p.T1292I	DO229016	COCA	ICGC	LVTPSIS	DEG_SCF_FBW7_1	0.7078
p.T1292I	DO218838	SKCA	ICGC	LVTPSIS	DEG_SCF_FBW7_1	0.7078
p.E1302K	DO229459	SKCA	ICGC	LVTPSIS	DEG_SCF_FBW7_1	0.1667
p.P1293R	SIDM00422	Hodgkin's Lymphoma	GDSC	LVTPSIS	DEG_SCF_FBW7_1	0.7512
p.P1293R	ACH-001203	Lymphoma	CCLE	LVTPSIS	DEG_SCF_FBW7_1	0.7512
p.P1293R	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	LVTPSIS	DEG_SCF_FBW7_1	0.7512
p.E1285Q	SIDM01042	Breast Carcinoma	GDSC	LVTPSIS	DEG_SCF_FBW7_1	0.1944
p.E1285Q	ACH-001065	Breast Cancer	CCLE	LVTPSIS	DEG_SCF_FBW7_1	0.1944
p.E1285Q	EVSA-T	breast	COSMIC	LVTPSIS	DEG_SCF_FBW7_1	0.1944
p.L1301I	SIDM01588	Endometrial Carcinoma	GDSC	LVTPSIS	DEG_SCF_FBW7_1	0.1944
p.L1301I	ACH-000993	Endometrial/Uterine Cancer	CCLE	LVTPSIS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VUA4	Zinc finger protein 318	DEG_SCF_FBW7_1	1290:1296	LVTPSIS	FBXW7	0.9968	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons