DegronMD

Uniprot ID: P40337

Source protein: von Hippel-Lindau disease tumor suppressor

Source gene: VHL

Class: LIG_APCC_ABBA_1

Location: 116:121

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7835

ASA_SCORE: 22.7833

COIL: 0.1155

CONS_SCORE: 0.7701

DSS_SCORE: 0.145

HELIX: 0.0052

FCONS_SCORE: 1.311

RIG_SCORE: 0.8385

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H115N	TCGA-3Z-A93Z	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	0.3056
p.H115N	TCGA-A3-3382	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	0.3056
p.H115N	TCGA-CJ-4643	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	0.3056
p.H115N	TCGA-CZ-5470	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	0.3056
p.R113Q	TCGA-4Z-AA80	BLCA	TCGA	LWLFRD	LIG_APCC_ABBA_1	0.25
p.R113Q	DO218986	BLCA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.25
p.G114A	TCGA-A3-3331	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	0.2778
p.R107P	TCGA-A3-3380	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	0.0833
p.R107P	DO16813	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.0833
p.R107P	DO232126	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.0833
p.R107P	DO233565	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.0833
p.N131K	TCGA-A3-A8OX	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	0.0556
p.N131K	TCGA-DV-A4VX	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	0.0556
p.N131K	TCGA-XQ-A8TA	PRAD	TCGA	LWLFRD	LIG_APCC_ABBA_1	0.0556
p.N131K	DO49690	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.0556
p.N131K	DO223832	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.0556
p.N131K	DO223662	PRAD	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.0556
p.L128H	TCGA-B0-5088	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	0.1389
p.L128H	TCGA-BP-5182	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	0.1389
p.L128H	TCGA-CZ-5458	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	0.1389
p.L128H	DO18552	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.1389
p.L128H	DO19317	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.1389
p.L128H	DO17742	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.1389
p.L118P	TCGA-B0-5094	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	0.6471
p.L118P	DO16769	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.6471
p.L118P	DO232150	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.6471
p.L118P	DO232174	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.6471
p.N131Y	TCGA-B0-5108	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	0.0556
p.N131Y	DO17343	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.0556
p.H110P	TCGA-B4-5843	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	0.1667
p.H110P	DO17781	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.1667
p.H110P	DO232161	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.1667
p.H110P	SIDM00188	Kidney Carcinoma	GDSC	LWLFRD	LIG_APCC_ABBA_1	0.1667
p.H110P	ACH-002139	Kidney Cancer	CCLE	LWLFRD	LIG_APCC_ABBA_1	0.1667
p.H110P	HA7-RCC	kidney	COSMIC	LWLFRD	LIG_APCC_ABBA_1	0.1667
p.D121Y	TCGA-B8-5163	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	0.7325
p.D121Y	TCGA-CJ-4638	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	0.7325
p.D121Y	DO20022	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.7325
p.D121Y	DO18978	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.7325
p.D121Y	DO46824	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.7325
p.V130F	TCGA-BP-4965	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	0.0833
p.V130F	TCGA-CW-5580	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	0.0833
p.V130F	DO19208	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.0833
p.V130F	DO18223	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.0833
p.V130F	DO233372	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.0833
p.V130F	DO233327	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.0833
p.V130F	DO233445	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.0833
p.V130F	SIDM00231	Kidney Carcinoma	GDSC	LWLFRD	LIG_APCC_ABBA_1	0.0833
p.V130F	ACH-002167	Kidney Cancer	CCLE	LWLFRD	LIG_APCC_ABBA_1	0.0833
p.V130F	NCC010	kidney	COSMIC	LWLFRD	LIG_APCC_ABBA_1	0.0833
p.H115Y	TCGA-BP-5169	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	0.3056
p.H115Y	SIDM00818	Kidney Carcinoma	GDSC	LWLFRD	LIG_APCC_ABBA_1	0.3056
p.H115Y	ACH-002190	Kidney Cancer	CCLE	LWLFRD	LIG_APCC_ABBA_1	0.3056
p.H115Y	RCC-JF	kidney	COSMIC	LWLFRD	LIG_APCC_ABBA_1	0.3056
p.V130D	TCGA-BP-5177	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	0.0833
p.V130D	DO16614	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.0833
p.V130D	DO233327	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.0833
p.V130D	ACH-000600	Kidney Cancer	CCLE	LWLFRD	LIG_APCC_ABBA_1	0.0833
p.S111N	TCGA-BP-5187	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	0.6389
p.S111N	TCGA-BP-5195	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	0.6389
p.S111N	DO18026	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.6389
p.S111N	DO17977	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.6389
p.S111N	DO17633	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.6389
p.S111N	DO220898	MELA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.6389
p.S111N	SIDM00232	Kidney Carcinoma	GDSC	LWLFRD	LIG_APCC_ABBA_1	0.6389
p.S111N	ACH-002168	Kidney Cancer	CCLE	LWLFRD	LIG_APCC_ABBA_1	0.6389
p.V130L	TCGA-BP-5201	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	0.0833
p.V130L	DO17206	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.0833
p.V130L	DO233310	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.0833
p.V130L	DO233597	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.0833
p.G127V	TCGA-BR-8487	STAD	TCGA	LWLFRD	LIG_APCC_ABBA_1	0.1667
p.G127V	DO47867	STAD	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.1667
p.W117C	TCGA-CJ-5684	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	0.5889
p.W117C	DO18482	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.5889
p.W117C	DO232172	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.5889
p.R120G	TCGA-CJ-6030	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	0.6457
p.R120G	DO19058	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.6457
p.R120G	DO233343	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.6457
p.L118F	TCGA-D1-A2G5	UCEC	TCGA	LWLFRD	LIG_APCC_ABBA_1	0.6981
p.L118F	DO40918	UCEC	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.6981
p.L116I	DO233913	GACA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.6063
p.L117P	DO19613	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.7582
p.L117P	DO17542	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.7582
p.L117Q	DO18711	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.7765
p.L117Q	DO233339	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.7765
p.R120P	DO19893	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.6401
p.L117V	DO19278	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.6765
p.L117V	DO16158	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.6765
p.L117V	DO47246	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.6765
p.L117V	DO232086	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.6765
p.L117V	DO233508	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.6765
p.V124D	DO20565	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.25
p.C121R	DO20446	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.8301
p.R126G	DO20879	KIRP	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.1944
p.L129V	DO229353	LAML	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.1111
p.C121Y	DO47060	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.7087
p.I109N	DO46847	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.1389
p.Y112C	DO233359	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.6667
p.D126E	DO233360	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.1944
p.S111R	DO233383	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.6389
p.S111R	DO233392	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.6389
p.S111R	DO233333	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.6389
p.S111G	DO233329	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.6389
p.S111G	ACH-001194	Kidney Cancer	CCLE	LWLFRD	LIG_APCC_ABBA_1	0.6389
p.K118N	DO233320	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.6918
p.H115Q	DO233338	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.3056
p.H115Q	SIDM01335	Kidney Carcinoma	GDSC	LWLFRD	LIG_APCC_ABBA_1	0.3056
p.H115Q	ACH-000513	Kidney Cancer	CCLE	LWLFRD	LIG_APCC_ABBA_1	0.3056
p.L122P	DO232145	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.3056
p.S111I	DO232141	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.6389
p.S111I	SIDM00119	Non-Small Cell Lung Carcinoma	GDSC	LWLFRD	LIG_APCC_ABBA_1	0.6389
p.S111I	ACH-000706	Lung Cancer	CCLE	LWLFRD	LIG_APCC_ABBA_1	0.6389
p.W117L	DO232142	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.5904
p.W117L	DO232129	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.5904
p.W117L	DO233515	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.5904
p.V129D	DO233421	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.1111
p.L128I	DO232107	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.1389
p.H115R	DO232119	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.3056
p.L128P	DO233443	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.1389
p.W117G	DO232120	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.6714
p.V124L	DO232130	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.25
p.V114L	DO233598	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.2778
p.E119D	DO233563	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.6758
p.L122H	DO233580	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.3056
p.V125G	DO233583	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LWLFRD

Degron related mutations and impact score

Drug responses associated with VHL mutations

All proteins holding degron of LWLFRD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P40337	von Hippel-Lindau disease tumor suppressor	LIG_APCC_ABBA_1	116:121	LWLFRD	APC,CDC20,FZR1	0.7835	More...