DegronMD - P40337(VHL)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H115N	TCGA-3Z-A93Z	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.3056
p.H115N	TCGA-A3-3382	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.3056
p.H115N	TCGA-CJ-4643	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.3056
p.H115N	TCGA-CZ-5470	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.3056
p.R113Q	TCGA-4Z-AA80	BLCA	TCGA	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.25
p.R113Q	DO218986	BLCA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.25
p.G114A	TCGA-A3-3331	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.2778
p.R107P	TCGA-A3-3380	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0833
p.R107P	DO16813	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0833
p.R107P	DO232126	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0833
p.R107P	DO233565	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0833
p.N131K	TCGA-A3-A8OX	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0556
p.N131K	TCGA-DV-A4VX	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0556
p.N131K	TCGA-XQ-A8TA	PRAD	TCGA	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0556
p.N131K	DO49690	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0556
p.N131K	DO223832	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0556
p.N131K	DO223662	PRAD	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0556
p.E52K	TCGA-AZ-6599	COAD	TCGA	PRPVLRSVN	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.1389
p.E52K	DO10606	COAD	ICGC	PRPVLRSVN	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.1389
p.S65W	TCGA-B0-5077	KIRC	TCGA	PRPVLRSVN	DEG_APCC_DBOX_1	59:67	Mutation altering degron motif	0.6763
p.S65W	DO18412	KIRC	ICGC	PRPVLRSVN	DEG_APCC_DBOX_1	59:67	Mutation altering degron motif	0.6763
p.S65W	ACH-000272	Kidney Cancer	CCLE	PRPVLRSVN	DEG_APCC_DBOX_1	59:67	Mutation altering degron motif	0.6763
p.L128H	TCGA-B0-5088	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1389
p.L128H	TCGA-BP-5182	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1389
p.L128H	TCGA-CZ-5458	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1389
p.L128H	DO18552	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1389
p.L128H	DO19317	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1389
p.L128H	DO17742	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1389
p.L118P	TCGA-B0-5094	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.6471
p.L118P	DO16769	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.6471
p.L118P	DO232150	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.6471
p.L118P	DO232174	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.6471
p.V74D	TCGA-B0-5097	KIRC	TCGA	PRPVLRSVN	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.1389
p.V74D	TCGA-BP-5175	KIRC	TCGA	PRPVLRSVN	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.1389
p.V74D	DO19370	KIRC	ICGC	PRPVLRSVN	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.1389
p.V74D	DO16153	KIRC	ICGC	PRPVLRSVN	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.1389
p.V74D	DO233481	RECA	ICGC	PRPVLRSVN	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.1389
p.N131Y	TCGA-B0-5108	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0556
p.N131Y	DO17343	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0556
p.H110P	TCGA-B4-5843	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1667
p.H110P	DO17781	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1667
p.H110P	DO232161	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1667
p.H110P	SIDM00188	Kidney Carcinoma	GDSC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1667
p.H110P	ACH-002139	Kidney Cancer	CCLE	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1667
p.H110P	HA7-RCC	kidney	COSMIC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1667
p.D121Y	TCGA-B8-5163	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.7325
p.D121Y	TCGA-CJ-4638	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.7325
p.D121Y	DO20022	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.7325
p.D121Y	DO18978	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.7325
p.D121Y	DO46824	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.7325
p.V130F	TCGA-BP-4965	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0833
p.V130F	TCGA-CW-5580	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0833
p.V130F	DO19208	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0833
p.V130F	DO18223	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0833
p.V130F	DO233372	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0833
p.V130F	DO233327	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0833
p.V130F	DO233445	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0833
p.V130F	SIDM00231	Kidney Carcinoma	GDSC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0833
p.V130F	ACH-002167	Kidney Cancer	CCLE	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0833
p.V130F	NCC010	kidney	COSMIC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0833
p.H115Y	TCGA-BP-5169	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.3056
p.H115Y	SIDM00818	Kidney Carcinoma	GDSC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.3056
p.H115Y	ACH-002190	Kidney Cancer	CCLE	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.3056
p.H115Y	RCC-JF	kidney	COSMIC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.3056
p.V130D	TCGA-BP-5177	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0833
p.V130D	DO16614	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0833
p.V130D	DO233327	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0833
p.V130D	ACH-000600	Kidney Cancer	CCLE	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0833
p.S111N	TCGA-BP-5187	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation blocking phosphorylation signal	0.6389
p.S111N	TCGA-BP-5195	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation blocking phosphorylation signal	0.6389
p.S111N	DO18026	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation blocking phosphorylation signal	0.6389
p.S111N	DO17977	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation blocking phosphorylation signal	0.6389
p.S111N	DO17633	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation blocking phosphorylation signal	0.6389
p.S111N	DO220898	MELA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation blocking phosphorylation signal	0.6389
p.S111N	SIDM00232	Kidney Carcinoma	GDSC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation blocking phosphorylation signal	0.6389
p.S111N	ACH-002168	Kidney Cancer	CCLE	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation blocking phosphorylation signal	0.6389
p.V130L	TCGA-BP-5201	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0833
p.V130L	DO17206	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0833
p.V130L	DO233310	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0833
p.V130L	DO233597	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.0833
p.G127V	TCGA-BR-8487	STAD	TCGA	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1667
p.G127V	DO47867	STAD	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1667
p.W117C	TCGA-CJ-5684	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.5889
p.W117C	DO18482	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.5889
p.W117C	DO232172	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.5889
p.R120G	TCGA-CJ-6030	KIRC	TCGA	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.6457
p.R120G	DO19058	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.6457
p.R120G	DO233343	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.6457
p.L118F	TCGA-D1-A2G5	UCEC	TCGA	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.6981
p.L118F	DO40918	UCEC	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.6981
p.L116I	DO233913	GACA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.6063
p.P71R	DO233900	GACA	ICGC	PRPVLRSVN	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.2222
p.L117P	DO19613	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.7582
p.L117P	DO17542	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.7582
p.V74G	DO17085	KIRC	ICGC	PRPVLRSVN	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.1389
p.L117Q	DO18711	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.7765
p.L117Q	DO233339	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.7765
p.R120P	DO19893	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.6401
p.L117V	DO19278	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.6765
p.L117V	DO16158	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.6765
p.L117V	DO47246	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.6765
p.L117V	DO232086	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.6765
p.L117V	DO233508	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.6765
p.V124D	DO20565	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.25
p.C121R	DO20446	KIRC	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.8301
p.V62M	DO18839	KIRC	ICGC	PRPVLRSVN	DEG_APCC_DBOX_1	59:67	Mutation altering degron motif	0.6097
p.R126G	DO20879	KIRP	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1944
p.L129V	DO229353	LAML	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1111
p.C121Y	DO47060	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.7087
p.S65L	DO47156	RECA	ICGC	PRPVLRSVN	DEG_APCC_DBOX_1	59:67	Mutation altering degron motif	0.6556
p.S65L	DO233374	RECA	ICGC	PRPVLRSVN	DEG_APCC_DBOX_1	59:67	Mutation altering degron motif	0.6556
p.I109N	DO46847	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1389
p.Y112C	DO233359	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation blocking phosphorylation signal	0.6667
p.D126E	DO233360	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1944
p.S111R	DO233383	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation blocking phosphorylation signal	0.6389
p.S111R	DO233392	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation blocking phosphorylation signal	0.6389
p.S111R	DO233333	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation blocking phosphorylation signal	0.6389
p.S111G	DO233329	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation blocking phosphorylation signal	0.6389
p.S111G	ACH-001194	Kidney Cancer	CCLE	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation blocking phosphorylation signal	0.6389
p.K118N	DO233320	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.6918
p.H115Q	DO233338	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.3056
p.H115Q	SIDM01335	Kidney Carcinoma	GDSC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.3056
p.H115Q	ACH-000513	Kidney Cancer	CCLE	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.3056
p.L122P	DO232145	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.3056
p.S111I	DO232141	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation blocking phosphorylation signal	0.6389
p.S111I	SIDM00119	Non-Small Cell Lung Carcinoma	GDSC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation blocking phosphorylation signal	0.6389
p.S111I	ACH-000706	Lung Cancer	CCLE	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation blocking phosphorylation signal	0.6389
p.W117L	DO232142	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.5904
p.W117L	DO232129	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.5904
p.W117L	DO233515	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.5904
p.V129D	DO233421	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1111
p.L128I	DO232107	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1389
p.S65P	DO232116	RECA	ICGC	PRPVLRSVN	DEG_APCC_DBOX_1	59:67	Mutation altering degron motif	0.5641
p.H115R	DO232119	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.3056
p.L128P	DO233443	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.1389
p.W117G	DO232120	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.6714
p.V124L	DO232130	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.25
p.V114L	DO233598	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.2778
p.E119D	DO233563	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation altering degron motif	0.6758
p.L122H	DO233580	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.3056
p.V125G	DO233583	RECA	ICGC	LWLFRD	LIG_APCC_ABBA_1	116:121	Mutation rewiring degron network	0.2222
p.V74A	DO229253	THCA	ICGC	PRPVLRSVN	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.1389
p.E70D	SIDM00153	T-Lymphoblastic Leukemia	GDSC	PRPVLRSVN	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.25
p.E70D	ACH-000964	Leukemia	CCLE	PRPVLRSVN	DEG_APCC_DBOX_1	59:67	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VHL

UniProt ID: P40337

Entrez ID: 7428

Protein name: von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for VHL in